Print Email Facebook Twitter A semi-stochastic cell-based formalism to model the dynamics of migration of cells in colonies Title A semi-stochastic cell-based formalism to model the dynamics of migration of cells in colonies Author Vermolen, F.J. Gefen, A. Faculty Electrical Engineering, Mathematics and Computer Science Department Delft Institute of Applied Mathematics Date 2011-03-26 Abstract We consider the movement and viability of individual cells in cell colonies. Cell movement is assumed to take place as a result of sensing the strain energy density as a mechanical stimulus. The model is based on tracking the displacement and viability of each individual cell in a cell colony. Several applications are shown, such as the dynamics of filling a gap within a fibroblast colony and the invasion of a cell colony. Though based on simple principles, the model is qualitatively validated by experiments on living fibroblasts on a flat substrate. Subject cell migrationcell-based modelsemi-stochastic model To reference this document use: http://resolver.tudelft.nl/uuid:fb983000-5e2c-418e-8d22-b9d07ae62620 DOI https://doi.org/10.1007/s10237-011-0302-6 Publisher Springer ISSN 1617-7959 Source Biomechanics and Modeling in Mechanobiology, 11 (1-2), 2011 Part of collection Institutional Repository Document type journal article Rights © The Author(s) 2011. This article is published with open access at Springerlink.com Files PDF Vermolen_2011.pdf 1.45 MB Close viewer /islandora/object/uuid:fb983000-5e2c-418e-8d22-b9d07ae62620/datastream/OBJ/view