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Wehrens, Martijn (author), Krah, Laurens H.J. (author), Towbin, Benjamin D. (author), Hermsen, Rutger (author), Tans, S.J. (author)The inherent stochasticity of metabolism raises a critical question for understanding homeostasis: are cellular processes regulated in response to internal fluctuations? Here, we show that, in E. coli cells under constant external conditions, catabolic enzyme expression continuously responds to metabolic fluctuations. The underlying...journal article 2023
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McKenzie, R. (author), Keizer, Emma M. (author), Vink, J.N.A. (author), van Lopik, Jasper (author), Büke, F. (author), Kalkman, Vera (author), Fleck, Christian (author), Tans, S.J. (author), Brouns, S.J.J. (author)While CRISPR-Cas defence mechanisms have been studied on a population level, their temporal dynamics and variability in individual cells have remained unknown. Using a microfluidic device, time-lapse microscopy and mathematical modelling, we studied invader clearance in Escherichia coli across multiple generations. We observed that CRISPR...journal article 2022
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Büke, F. (author), Grilli, Jacopo (author), Cosentino Lagomarsino, Marco (author), Bokinsky, G.E. (author), Tans, S.J. (author)Growth and division are central to cell size. Bacteria achieve size homeostasis by dividing when growth has added a constant size since birth, termed the adder principle, by unknown mechanisms.<sup>1</sup><sup>,</sup><sup>2</sup> Growth is well known to be regulated by guanosine tetraphosphate (ppGpp), which controls diverse processes from...journal article 2022
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- Tans, S.J. (author), Geerligs, L.J. (author), Dekker, C. (author), Wu, J. (author), Wegner, G. (author) journal article 1997
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- Dekker, C. (author), Tans, S.J. (author), Oberndorff, B. (author), Meyer, R. (author), Venema, L.C. (author) journal article 1997
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- Dekker, C. (author), Tans, S.J. (author), Geerligs, L.J. (author), Bezryadin, A. (author), Wu, J. (author), Wegner, G. (author) journal article 1997
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- Tans, S.J. (author), Miedema, R. (author), Geerligs, L.J. (author), Dekker, C. (author), Wu, J. (author), Wegner, G. (author) journal article 1997