The damages caused by floods remain an issue in the Chi River Basin, Thailand. Therefore, an integrated flood management framework needs to be developed to minimize the negative effects of floods of different magnitude. In response, a hydrological model (SWAT) and a hydraulic (1D/2D SOBEK) model were integrated to simulate floods in detailed way and to analyse the current system. The developed modelling framework enabled to analyse the impacts of different structural and non-structural measures based on economic and technical efficiency criteria. An optimum combination of aforesaid measures was then chosen since it could considerably reduce flood extent and its damage. Additionally, the study illustrates the effects of land use changes on floods, which indicated little or no significant potential impact on flood regime at river basin level, but rather at sub-basin scale. This finding is important for a better understanding of the scale and direction of impacts of future developments.