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Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system

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These file attachments have been under embargo and were made available to the public after the embargo was lifted on 2 April 2012.

Author: Ke, H. (Washington Univ. St. Louis) · Erpelding, T. · Jankovic, L. · Wang, L.V. (Washington Univ. St. Louis)
Type:article
Date:2012-04-02
Embargo lifted:2012-04-02
Publisher: SPIE (International Society for Optical Engineering)
Institution: Philips Research
Source:Journal of Biomedical Optics; authors version
Identifier: MS 32.328
Keywords: photoacoustic imaging · thermoacoustic imaging · ultrasound imaging
Rights: (c) SPIE (International Society for Optical Engineering)

Abstract

We developed a tri-modality imaging system for breast cancer imagingby integrating photoacoustic (PA) and thermoacoustic (TA) imaging techniques into a modified commercial ultrasound scanner. Laser and microwave excitation pulses were interleaved to enable PA and TA dataacquisition in parallel at the rate of 10 frames per second. The performance of the tri-modality imaging system was evaluated in-vitrousing phantom samples. A plastic tube (7 mm inner diameter, 25 mm length) filled with 30 mM methylene blue dye placed at a depth of 8.4cm in chicken breast tissue was successfully detected in PA images with an ultrasonic bandwidth of 1–5 MHz. The SNR at this depth was 15dB after averaging 200 signal acquisitions. Similarly, a plastic tube (7 mm inner diameter, 25 mm length) filled with high concentration salt water placed at a depth of 5.1 cm in porcine fat tissue was successfully detected in TA images. A PA noise-equivalent-sensitivityto methylene blue solution of 260 nM was achieved in chicken tissueat a depth of 3.4 cm and with a laser fluence of 17 mJ/cm2.

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