These file attachments have been under embargo and were made available to the public after the embargo was lifted on 2 July 2012.
The integration of therapeutic interventions with diagnostic imaginghas been recognized as one of the next technological developments that will have a major impact on medical treatments. Therapeutic applications using ultrasound, for example thermal ablation, hyperthermia or ultrasound induced drug delivery, are examples for image-guidedinterventions that are currently investigated. While thermal ablation using MR-HIFU is entering the clinic, ultrasound mediated drug delivery is still in a research phase, but holds promise to enable newapplications in localized treatments. The use of ultrasound for thedelivery of drugs has been demonstrated in particular the field ofcardiology and oncology for a variety of therapeutics ranging from small drug molecules to biologics and nucleic acids exploiting temperature or pressure mediated delivery schemes.