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Find, Fight, Follow: Ultrasound triggered image-guided drug delivery

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These file attachments have been under embargo and were made available to the public after the embargo was lifted on 2 July 2012.

Author: Sanches, P.G. · Gruell, H. · Steinbach, O.C.
Type:article
Date:2012-07-02
Embargo lifted:2012-07-02
Publisher: Future Science Group
Institution: Philips Research
Source:Therapeutic Delivery; authors version
Identifier: MS 32.379
Keywords: invited paper
Rights: (c) Future Science Group

Abstract

The integration of therapeutic interventions with diagnostic imaginghas been recognized as one of the next technological developments that will have a major impact on medical treatments. Therapeutic applications using ultrasound, for example thermal ablation, hyperthermia or ultrasound induced drug delivery, are examples for image-guidedinterventions that are currently investigated. While thermal ablation using MR-HIFU is entering the clinic, ultrasound mediated drug delivery is still in a research phase, but holds promise to enable newapplications in localized treatments. The use of ultrasound for thedelivery of drugs has been demonstrated in particular the field ofcardiology and oncology for a variety of therapeutics ranging from small drug molecules to biologics and nucleic acids exploiting temperature or pressure mediated delivery schemes.

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