Print Email Facebook Twitter Spherical polyelectrolyte nanogels as templates to prepare hollow silica nanocarriers: observation by small angle X-ray scattering and TEM Title Spherical polyelectrolyte nanogels as templates to prepare hollow silica nanocarriers: observation by small angle X-ray scattering and TEM Author Han, Haoya (East China University of Science and Technology) Li, Li (East China University of Science and Technology) Tian, Yuchuan (East China University of Science and Technology) Wang, Yunwei (East China University of Science and Technology) Ye, Zhishuang (East China University of Science and Technology) Yang, Qingsong (East China University of Science and Technology) Wang, Y. (TU Delft ChemE/Advanced Soft Matter; East China University of Science and Technology) Von Klitzing, Regine (Technische Universität Darmstadt) Guo, Xuhong (East China University of Science and Technology; Shihezi University) Date 2017 Abstract Hollow silica nanoparticles were prepared through generating a silica layer in spherical polyelectrolyte nanogels (SPN), which consisted of a solid core of polystyrene (PS) and a shell of crosslinked poly(acrylic acid) (PAA), followed by removing the PS core via solvent dissolution. Small angle X-ray scattering (SAXS) in combination with TEM were employed to observe SPN, silica-polymer composite, and hollow silica nanoparticles. It was confirmed that SAXS is a powerful method to monitor the generation of silica layer in SPN. The density and thickness of generated silica layer in SPN were found to be tunable by controlling the crosslinking density of the templates. The porous structure and pH sensitivity of silica layer allowed the obtained hollow silica to be ideal carriers for controlled drug delivery. To reference this document use: http://resolver.tudelft.nl/uuid:6fc49203-b2da-46f3-b11b-362d1ee4330c DOI https://doi.org/10.1039/c7ra10011f ISSN 2046-2069 Source RSC Advances, 7 (76), 47877-47885 Part of collection Institutional Repository Document type journal article Rights © 2017 Haoya Han, Li Li, Yuchuan Tian, Yunwei Wang, Zhishuang Ye, Qingsong Yang, Y. Wang, Regine Von Klitzing, Xuhong Guo Files PDF c7ra10011f.pdf 2.07 MB Close viewer /islandora/object/uuid%3A6fc49203-b2da-46f3-b11b-362d1ee4330c/datastream/OBJ/view