The intermuscular 3–7 Hz drive is not affected by distal proprioceptive input in myoclonus-dystonia

The intermuscular 3–7 Hz drive is not affected by distal proprioceptive input in myoclonus-dystonia

Van der Meer, J.N.
Schouten, A.C.
Bour, L.J.
De Vlugt, E.
Van Rootselaar, A.F.
Van der Helm, F.C.T.
Tijssen, M.A.J.

Applied Sciences

Biomechanical Engineering

2010-02-16

In dystonia, both sensory malfunctioning and an abnormal intermuscular low-frequency drive of 3–7 Hz have been found, although cause and eVect are unknown. It is hypothesized that sensory processing is primarily disturbed and induces this drive. Accordingly, experimenter-controlled sensory input should be able to inXuence the frequency of the drive. In six genetically conWrmed myoclonus-dystonia (MD) patients and six matched controls, the low-frequency drive was studied with intermuscular coherence analysis. External perturbations were applied mechanically to the wrist joint in small frequency bands (0–4, 4–8 and 8–12 Hz; ‘angle protocol) and at single frequencies (1, 5, 7 and 9 Hz; ‘torque’ protocol). The low-frequency drive was found in the neck muscles of 4 MD patients. In these patients, its frequency did not shift due to the perturbation. In the torque protocol, the externally applied frequencies could be detected in all controls and in the two patients without the common drive. The common low-frequency drive was not be aVected by external perturbations in MD patients. Furthermore, the torque protocol did not induce intermuscular coherences at the applied frequencies in these patients, as was the case in healthy controls and in patients without the drive. This suggests that the dystonic 3–7 Hz drive is caused by a sensory-independent motor drive and sensory malfunctioning in MD might rather be a consequence than a cause of dystonia.

EEG
EMG
Dystonia
Proprioception
Sensorimotor integration

http://resolver.tudelft.nl/uuid:cb36e3f3-de76-40b2-b996-94abebc8ce63

https://doi.org/10.1007/s00221-010-2174-x

Springer

1432-1106

Experimental brain research, 202 (3), 2010

Institutional Repository

journal article

(c) 2010 The Author(s). This article is published with open access at Springerlink.com