Lichen simplex chronicus as an essential part of the dermatologic masquerade

Lichen simplex chronicus as an essential part of the dermatologic masquerade

Voicu, Cristiana (Polisano Clinic)
Tebeica, Tiberiu (Dr Leventer Centre)
Zanardelli, Matteo (Private company - Pharmacology)
Mangarov, Hristo (Medical Institute of Ministry of Interior (MVR))
Lotti, T. (TU Delft BT/Environmental Biotechnology; Sapienza-University of Rome)
Wollina, Uwe (Academic Teaching Hospital Dresden-Friedrichstadt)
Lotti, Jacopo (Sapienza-University of Rome)
França, Katlein (University of Miami Miller School of Medicine)
Batashki, Atanas (Medical University of Plovdiv)
Tchernev, Georgi (Medical Institute of Ministry of Interior (MVR))

2017

A 48 years old female patient had been suffering from the lesions presented for four years. They have started as small, pruritic patches which had been mechanically irritated and grew up in time. The patient had no associated comorbidities or allergies, and she was not under any medication. On physical examination, she presented one erythematous, exudative plaque, with dimensions of 2.5/4 cm, located on the proximal phalanx and interphalangeal articulation of the left thumb. All histopathological features were consistent with the diagnosis of lichen simplex chronicus. Some lesions of lichen simplex chronicus exhibit signs of pseudocarcinomatous, infundibular and sometimes eccrine ductal proliferation of keratinocytes. Although the pseudoinfiltrative aspect of the epithelial proliferation and its pronounced degree might mimic a well-differentiated lesion of squamous cell carcinoma, a lack of cellular atypia and atypical mitotic figures are features that do not support this diagnosis. On the other hand, long lasting lesions of lichen simplex chronicus may lead to alterations in the processes of keratinocyte proliferation and differentiation and eventually give rise to malignant transformation. The best treatment management is a psychodermatological approach, a combination of skin care with psychotherapy, in order to prevent relapses.

Carcinoma
Histology
Lichen simplex
Prurigo nodularis
Surgery

http://resolver.tudelft.nl/uuid:0e20cd03-7f25-4ef2-9f04-ad0db758ff0c

https://doi.org/10.3889/oamjms.2017.133

Open Access Macedonian Journal of Medical Sciences, 5 (4 Special Issue GlobalDermatology), 556-557

Institutional Repository

journal article

© 2017 Cristiana Voicu, Tiberiu Tebeica, Matteo Zanardelli, Hristo Mangarov, T. Lotti, Uwe Wollina, Jacopo Lotti, Katlein França, Atanas Batashki, Georgi Tchernev