Print Email Facebook Twitter Analysis of attenuation coefficient estimation in Fourier-domain OCT of semi-infinite media Title Analysis of attenuation coefficient estimation in Fourier-domain OCT of semi-infinite media Author Ghafaryasl, B. (TU Delft ImPhys/Computational Imaging; Rotterdam Eye Hospital) Vermeer, Koenraad A. (Rotterdam Eye Hospital) Kalkman, J. (TU Delft ImPhys/Computational Imaging) Dore-Callewaert, T.W.J. (TU Delft ImPhys/Computational Imaging) Boer, Johannes F.D.E. (Vrije Universiteit Amsterdam) van Vliet, L.J. (TU Delft ImPhys/Computational Imaging; TU Delft Applied Sciences) Faculty Applied Sciences Date 2020 Abstract The attenuation coefficient (AC) is an optical property of tissue that can be estimated from optical coherence tomography (OCT) data. In this paper, we aim to estimate the AC accurately by compensating for the shape of the focused beam. For this, we propose a method to estimate the axial PSF model parameters and AC by fitting a model for an OCT signal in a homogenous sample to the recorded OCT signal. In addition, we employ numerical analysis to obtain the theoretical optimal precision of the estimated parameters for different experimental setups. Finally, the method is applied to OCT B-scans obtained from homogeneous samples. The numerical and experimental results show accurate estimations of the AC and the focus location when the focus is located inside the sample. To reference this document use: http://resolver.tudelft.nl/uuid:18482bfc-8189-4e2f-83e7-d7a56879625b DOI https://doi.org/10.1364/BOE.403283 ISSN 2156-7085 Source Biomedical Optical Express, 11 (11), 6093-6107 Part of collection Institutional Repository Document type journal article Rights © 2020 B. Ghafaryasl, Koenraad A. Vermeer, J. Kalkman, T.W.J. Dore-Callewaert, Johannes F.D.E. Boer, L.J. van Vliet Files PDF boe_11_11_6093.pdf 1.44 MB Close viewer /islandora/object/uuid:18482bfc-8189-4e2f-83e7-d7a56879625b/datastream/OBJ/view