Print Email Facebook Twitter A compact matrix model for atrial electrograms for tissue conductivity estimation Title A compact matrix model for atrial electrograms for tissue conductivity estimation Author Abdi, Bahareh (TU Delft Signal Processing Systems) Hendriks, R.C. (TU Delft Signal Processing Systems) van der Veen, A.J. (TU Delft Signal Processing Systems) de Groot, Natasja M.S. (Erasmus MC) Date 2019 Abstract Finding the hidden parameters of the cardiac electrophysiological model would help to gain more insight on the mechanisms underlying atrial fibrillation, and subsequently, facilitate the diagnosis and treatment of the disease in later stages. In this work, we aim to estimate tissue conductivity from recorded electrograms as an indication of tissue (mal)functioning. To do so, we first develop a simple but effective forward model to replace the computationally intensive reaction-diffusion equations governing the electrical propagation in tissue. Using the simplified model, we present a compact matrix model for electrograms based on conductivity. Subsequently, we exploit the simplicity of the compact model to solve the ill-posed inverse problem of estimating tissue conductivity. The algorithm is demonstrated on simulated data as well as on clinically recorded data. The results show that the model allows to efficiently estimate the conductivity map. In addition, based on the estimated conductivity, realistic electrograms can be regenerated demonstrating the validity of the model. Subject Atrial fibrillationConductivity estimationElectrode arrayElectrogramsElectrophysiological modelInverse problemReaction-diffusion equation To reference this document use: http://resolver.tudelft.nl/uuid:1b5ccec1-766e-4e52-b94a-468bf6b1a519 DOI https://doi.org/10.1016/j.compbiomed.2019.02.012 Embargo date 2019-08-21 ISSN 0010-4825 Source Computers in Biology and Medicine, 107, 284-291 Bibliographical note Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. Part of collection Institutional Repository Document type journal article Rights © 2019 Bahareh Abdi, R.C. Hendriks, A.J. van der Veen, Natasja M.S. de Groot Files PDF mainpdf.pdf 2.65 MB Close viewer /islandora/object/uuid:1b5ccec1-766e-4e52-b94a-468bf6b1a519/datastream/OBJ/view