Print Email Facebook Twitter Membrane area gain and loss during cytokinesis Title Membrane area gain and loss during cytokinesis Author Frey, F.F.F. (TU Delft BN/Timon Idema Lab; Kavli institute of nanoscience Delft) Idema, T. (TU Delft BN/Timon Idema Lab; Kavli institute of nanoscience Delft) Date 2022 Abstract In cytokinesis of animal cells, the cell is symmetrically divided into two. Since the cell's volume is conserved, the projected area has to increase to allow for the change of shape. Here we aim to predict how membrane gain and loss adapt during cytokinesis. We work with a kinetic model in which membrane turnover depends on membrane tension and cell shape. We apply this model to a series of calculated vesicle shapes as a proxy for the shape of dividing cells. We find that the ratio of kinetic turnover parameters changes nonmonotonically with cell shape, determined by the dependence of exocytosis and endocytosis on membrane curvature. Our results imply that controlling membrane turnover will be crucial for the successful division of artificial cells. To reference this document use: http://resolver.tudelft.nl/uuid:275d9a3a-3bce-4f3c-a64b-dc8eaee38d02 DOI https://doi.org/10.1103/PhysRevE.106.024401 ISSN 2470-0045 Source Physical Review E, 106 (2) Part of collection Institutional Repository Document type journal article Rights © 2022 F.F.F. Frey, T. Idema Files PDF PhysRevE.106.024401.pdf 1.18 MB Close viewer /islandora/object/uuid:275d9a3a-3bce-4f3c-a64b-dc8eaee38d02/datastream/OBJ/view