Print Email Facebook Twitter Cingulate networks associated with gray matter loss in Parkinson's disease show high expression of cholinergic genes in the healthy brain Title Cingulate networks associated with gray matter loss in Parkinson's disease show high expression of cholinergic genes in the healthy brain Author Keo, D.L. (TU Delft Pattern Recognition and Bioinformatics; Universiteit Leiden) Dzyubachyk, Oleh (Leiden University Medical Center) van der Grond, Jeroen (Leiden University Medical Center) Hafkemeijer, Anne (Leiden University Medical Center; Universiteit Leiden) van de Berg, Wilma D.J. (Amsterdam UMC) van Hilten, Jacobus J. (Leiden University Medical Center) Reinders, M.J.T. (TU Delft Pattern Recognition and Bioinformatics; Leiden University Medical Center) Mahfouz, A.M.E.T.A. (TU Delft Pattern Recognition and Bioinformatics; Leiden University Medical Center) Date 2021 Abstract Structural covariance networks are able to identify functionally organized brain regions by gray matter volume covariance across a population. We examined the transcriptomic signature of such anatomical networks in the healthy brain using postmortem microarray data from the Allen Human Brain Atlas. A previous study revealed that a posterior cingulate network and anterior cingulate network showed decreased gray matter in brains of Parkinson's disease patients. Therefore, we examined these two anatomical networks to understand the underlying molecular processes that may be involved in Parkinson's disease. Whole brain transcriptomics from the healthy brain revealed upregulation of genes associated with serotonin, GPCR, GABA, glutamate, and RAS-signaling pathways. Our results also suggest involvement of the cholinergic circuit, in which genes NPPA, SOSTDC1, and TYRP1 may play a functional role. Finally, both networks were enriched for genes associated with neuropsychiatric disorders that overlap with Parkinson's disease symptoms. The identified genes and pathways contribute to healthy functions of the posterior and anterior cingulate networks and disruptions to these functions may in turn contribute to the pathological and clinical events observed in Parkinson's disease. Subject Allen Human Brain Atlasbrain imagingneuroinformaticsspatial transcriptomicsstructural covariance networks To reference this document use: http://resolver.tudelft.nl/uuid:2c519f35-0c46-459b-986f-2cb4a750e5c1 DOI https://doi.org/10.1111/ejn.15216 ISSN 0953-816X Source European journal of neuroscience, 53 (11), 3727-3739 Part of collection Institutional Repository Document type journal article Rights © 2021 D.L. Keo, Oleh Dzyubachyk, Jeroen van der Grond, Anne Hafkemeijer, Wilma D.J. van de Berg, Jacobus J. van Hilten, M.J.T. Reinders, A.M.E.T.A. Mahfouz Files PDF ejn.15216.pdf 782.37 KB Close viewer /islandora/object/uuid:2c519f35-0c46-459b-986f-2cb4a750e5c1/datastream/OBJ/view