Print Email Facebook Twitter On the dynamics of StemBells: Microbubble-conjugated stem cells for ultrasound-controlled delivery Title On the dynamics of StemBells: Microbubble-conjugated stem cells for ultrasound-controlled delivery Author Kokhuis, Tom J A (Erasmus MC; Netherlands Heart Institute) Naaijkens, Benno A. (Netherlands Heart Institute; Amsterdam UMC) Juffermans, Lynda J.M. (Netherlands Heart Institute; Amsterdam UMC) Kamp, Otto (Netherlands Heart Institute; Amsterdam UMC) van der Steen, A.F.W. (TU Delft ImPhys/Acoustical Wavefield Imaging; Erasmus MC; Netherlands Heart Institute; Shenzhen Institutes of Advanced Technology) Versluis, Michel (University of Twente) de Jong, N. (TU Delft ImPhys/Acoustical Wavefield Imaging; Erasmus MC; Netherlands Heart Institute) Date 2017-07-10 Abstract The use of stem cells for regenerative tissue repair is promising but hampered by the low number of cells delivered to the site of injury. To increase the delivery, we propose a technique in which stem cells are linked to functionalized microbubbles, creating echogenic complex dubbed StemBells. StemBells are highly susceptible to acoustic radiation force which can be employed after injection to push the StemBells locally to the treatment site. To optimally benefit from the delivery technique, a thorough characterization of the dynamics of StemBells during ultrasound exposure is needed. Using high-speed optical imaging, we study the dynamics of StemBells as a function of the applied frequency from which resonance curves were constructed. A theoretical model, based on a modified Rayleigh-Plesset type equation, captured the experimental resonance characteristics and radial dynamics in detail. To reference this document use: http://resolver.tudelft.nl/uuid:3d792a97-a204-483f-94b5-6bd82f278b2f DOI https://doi.org/10.1063/1.4993172 Embargo date 2018-07-11 ISSN 0003-6951 Source Applied Physics Letters, 111 (2) Part of collection Institutional Repository Document type journal article Rights © 2017 Tom J A Kokhuis, Benno A. Naaijkens, Lynda J.M. Juffermans, Otto Kamp, A.F.W. van der Steen, Michel Versluis, N. de Jong Files PDF 1.4993172.pdf 1.36 MB Close viewer /islandora/object/uuid:3d792a97-a204-483f-94b5-6bd82f278b2f/datastream/OBJ/view