Print Email Facebook Twitter MRI-Ready Actuation System for a Self-Propelling Needle Title MRI-Ready Actuation System for a Self-Propelling Needle: A Design and Experimental Approach Author Bloemberg, Jette (TU Delft Mechanical, Maritime and Materials Engineering) Contributor Trauzettel, F. (mentor) Dodou, D. (mentor) Breedveld, P. (mentor) Jovanova, J. (graduation committee) Langelaar, M. (graduation committee) Degree granting institution Delft University of Technology Programme Mechanical Engineering | BioMechanical Design Date 2021-02-17 Abstract Standard treatment methods for prostate cancer often result in side-effects because of damage to the surrounding tissue. Magnetic resonance imaging (MRI) guided focal laser ablation to treat prostate cancer reduces the risk of adverse effects by preserving noncancerous tissue. Prostate cancer diagnosis and focal laser ablation treatment both require the insertion of a needle for biopsy and optical fibre positioning. The insertion of needles in soft tissues causes tissue motion and deformation, resulting in tissue damage. In this study, we propose an MRI-ready actuation system for a needle that can be inserted into tissue with a zero external push force and without buckling. The zero external push force is achieved by moving parallel needle segments in a reciprocating manner. The actuation unit’s design inspired by the click-pen mechanism actuates the reciprocating motion of six parallel needle segments by solely a discrete manual translating actuation as its input. A prototype, called the Ovipositor MRI-Needle, was built using 3D printed parts and six 0.25-mm diameter Nitinol rods. Experimental validation of the Ovipositor MRI-Needle in ex vivo human prostate tissue inside a preclinical MRI scanner showed that the needle could advance in three out of five measurements through the tissue. The Ovipositor MRI-Needle is a step forward in the direction of developing a self-propelling needle for MRI-guided transperineal laser ablation to treat prostate cancer. Subject Medical needlemagnetic resonance imagingadditive manufacturingmanual actuatorbiologically inspired design To reference this document use: http://resolver.tudelft.nl/uuid:3eb89f98-72a6-4334-9bcb-e382ea9bcf84 Embargo date 2023-03-01 Part of collection Student theses Document type master thesis Rights © 2021 Jette Bloemberg Files PDF Master_Thesis_Report_Jett ... emberg.pdf 18.68 MB Close viewer /islandora/object/uuid:3eb89f98-72a6-4334-9bcb-e382ea9bcf84/datastream/OBJ/view