Dynamic information flow based on EEG and diffusion MRI in stroke

Dynamic information flow based on EEG and diffusion MRI in stroke: A proof-of-principle study

Filatova, O.G. (TU Delft Biomechatronics & Human-Machine Control)
Yang, Y. (TU Delft Biomechatronics & Human-Machine Control; Northwestern University)
Dewald, J.P.A. (TU Delft Biomechatronics & Human-Machine Control; Northwestern University)
Tian, Runfeng (Student TU Delft)
Maceira-Elvira, Pablo (Swiss Federal Institute of Technology; Student TU Delft)
Takeda, Yusuke (RIKEN Center for Emergent Matter Science (CEMS); ATR)
Kwakkel, Gert (Amsterdam UMC)
Yamashita, Okito (RIKEN Center for Emergent Matter Science (CEMS); ATR)
van der Helm, F.C.T. (TU Delft Biomechatronics & Human-Machine Control; Northwestern University)

2018

In hemiparetic stroke, functional recovery of paretic limb may occur with the reorganization of neural networks in the brain. Neuroimaging techniques, such as magnetic resonance imaging (MRI), have a high spatial resolution which can be used to reveal anatomical changes in the brain following a stroke. However, low temporal resolution of MRI provides less insight of dynamic changes of brain activity. In contrast, electro-neurophysiological techniques, such as electroencephalography (EEG), have an excellent temporal resolution to measure such transient events, however are hindered by its low spatial resolution. This proof-of-principle study assessed a novel multimodal brain imaging technique namely Variational Bayesian Multimodal Encephalography (VBMEG), which aims to improve the spatial resolution of EEG for tracking the information flow inside the brain and its changes following a stroke. The limitations of EEG are complemented by constraints derived from anatomical MRI and diffusion weighted imaging (DWI). EEG data were acquired from individuals suffering from a stroke as well as able-bodied participants while electrical stimuli were delivered sequentially at their index finger in the left and right hand, respectively. The locations of active sources related to this stimulus were precisely identified, resulting in high Variance Accounted For (VAF above 80%). An accurate estimation of dynamic information flow between sources was achieved in this study, showing a high VAF (above 90%) in the cross-validation test. The estimated dynamic information flow was compared between chronic hemiparetic stroke and able-bodied individuals. The results demonstrate the feasibility of VBMEG method in revealing the changes of information flow in the brain after stroke. This study verified the VBMEG method as an advanced computational approach to track the dynamic information flow in the brain following a stroke. This may lead to the development of a quantitative tool for monitoring functional changes of the cortical neural networks after a unilateral brain injury and therefore facilitate the research into, and the practice of stroke rehabilitation.

Brain dynamics
Diffusion MRI
EEG
Somatosensory evoked potentials (SEP)
Stroke

http://resolver.tudelft.nl/uuid:4db1637e-554b-4c6e-9c92-99cab869ca3f

https://doi.org/10.3389/fncir.2018.00079

1662-5110

Frontiers in Neural Circuits, 12

Institutional Repository

journal article

© 2018 O.G. Filatova, Y. Yang, J.P.A. Dewald, Runfeng Tian, Pablo Maceira-Elvira, Yusuke Takeda, Gert Kwakkel, Okito Yamashita, F.C.T. van der Helm