Print Email Facebook Twitter Mimicking the nuclear pore complex using nanopores Title Mimicking the nuclear pore complex using nanopores Author Ananth, A.N. (TU Delft BN/Cees Dekker Lab) Contributor Dekker, C. (promotor) Degree granting institution Delft University of Technology Date 2018-04-10 Abstract Nuclear pore complexes acts as a gatekeeper for molecular transport between the nucleus and the cytoplasm in eukaryotic cells. The central NPC channel is filled with intrinsically disordered FG domains (phenylalanine (F), glycine (G)) that are responsible for the fascinating selectivity of NPCs, for which the underlying mechanism is still under considerable debate. In this thesis, a minimalistic mimic of (NPCs) was constructed using solid-state nanopore and DNA origami to study the spatial arrangement and transport process. Subject Single-moleculesolid-state nanoporenuclear pore complexproteinsionic conductanceDNA origamisurface chemistry To reference this document use: https://doi.org/10.4233/uuid:4f0141e7-9b97-4ed4-86be-9b885b420423 ISBN 9789085933427 Part of collection Institutional Repository Document type doctoral thesis Rights © 2018 A.N. Ananth Files PDF PhD_thesis_Ananth.pdf 11.63 MB Close viewer /islandora/object/uuid:4f0141e7-9b97-4ed4-86be-9b885b420423/datastream/OBJ/view