Aortic haemodynamics and wall stress analysis following arch aneurysm repair using a single-branched endograft

Aortic haemodynamics and wall stress analysis following arch aneurysm repair using a single-branched endograft

Sengupta, Sampad (Imperial College London)
Yuan, Xun (The Royal Brompton and Harefield NHS Foundation Trust; Imperial College London)
Maga, L.M. (TU Delft Medical Instruments & Bio-Inspired Technology; Politecnico di Milano)
Dr Pirola, S.P. (TU Delft Medical Instruments & Bio-Inspired Technology)
Nienaber, Christoph A. (The Royal Brompton and Harefield NHS Foundation Trust; Imperial College London)
Xu, Xiao Yun (Imperial College London)

2023

Introduction: Thoracic endovascular aortic repair (TEVAR) of the arch is challenging given its complex geometry and the involvement of supra-aortic arteries. Different branched endografts have been designed for use in this region, but their haemodynamic performance and the risk for post-intervention complications are not yet clear. This study aims to examine aortic haemodynamics and biomechanical conditions following TVAR treatment of an aortic arch aneurysm with a two-component single-branched endograft. Methods: Computational fluid dynamics and finite element analysis were applied to a patient-specific case at different stages: pre-intervention, post-intervention and follow-up. Physiologically accurate boundary conditions were used based on available clinical information. Results: Computational results obtained from the post-intervention model confirmed technical success of the procedure in restoring normal flow to the arch. Simulations of the follow-up model, where boundary conditions were modified to reflect change in supra-aortic vessel perfusion observed on the follow-up scan, predicted normal flow patterns but high levels of wall stress (up to 1.3M MPa) and increased displacement forces in regions at risk of compromising device stability. This might have contributed to the suspected endoleaks or device migration identified at the final follow up. Discussion: Our study demonstrated that detailed haemodynamic and biomechanical analysis can help identify possible causes for post-TEVAR complications in a patient-specific setting. Further refinement and validation of the computational workflow will allow personalised assessment to aid in surgical planning and clinical decision making.

aortic arch
computational fluid dynamics
endograft
finite element analysis
TEVAR

http://resolver.tudelft.nl/uuid:5ee3066b-25ba-4528-9a9b-f116be0a7076

https://doi.org/10.3389/fcvm.2023.1125110

2297-055X

Frontiers in Cardiovasculair Medicine, 10

Institutional Repository

journal article

© 2023 Sampad Sengupta, Xun Yuan, L.M. Maga, S.P. Dr Pirola, Christoph A. Nienaber, Xiao Yun Xu