Print Email Facebook Twitter Gold nanoparticles: A novel application of spectral imaging in proteomics - preliminary results Title Gold nanoparticles: A novel application of spectral imaging in proteomics - preliminary results Author Dietrich, H.R.C. Young, I.T. Garini, Y. Faculty Applied Sciences Department Imaging Science and Technology Date 2005-03-23 Abstract The intense research in proteomics is demanding for fast, reliable and easy-to-use methods in order to study the proteome. In this proceeding we report the development of such a novel research tool based on spectral imaging and Resonance Light Scattering gold particles. This method will allow the study of DNA-protein interactions. We suggest a broad range of applications: the screening of proteins binding to a specific DNA sequence, the analysis of binding affinities between protein and DNA, and the investigation of the influence of environmental conditions on the binding. We will explain the principle, first experiments and first results based on Brownian motion. Subject gold nanoparticlessingle molecule detectionsurface plasmonsproteomicsDNA-protein interactionsprotein-protein interactions To reference this document use: http://resolver.tudelft.nl/uuid:6f31fd73-875c-4162-a3bd-93e4fd661d70 Publisher SPIE ISSN 0277-786X Source Proceedings of SPIE, 2005 vol. 5694 Part of collection Institutional Repository Document type conference paper Rights (c)2005 Dietrich, H.R.C., Young, I.T., Garini, Y. Files PDF GoldHeidelinde.pdf 369.41 KB Close viewer /islandora/object/uuid:6f31fd73-875c-4162-a3bd-93e4fd661d70/datastream/OBJ/view