Applying Non-canonical Redox Cofactors in Fermentation Processes

Weusthuis, Ruud A.; Folch, Pauline L.; Pozo-Rodríguez, Ana; Paul, C.E.

doi:10.1016/j.isci.2020.101471

Applying Non-canonical Redox Cofactors in Fermentation Processes

Title

Applying Non-canonical Redox Cofactors in Fermentation Processes

Author

Weusthuis, Ruud A. (Wageningen University & Research)
Folch, Pauline L. (Wageningen University & Research)
Pozo-Rodríguez, Ana (Wageningen University & Research)
Paul, C.E. (TU Delft BT/Biocatalysis)

Date

2020

Abstract

Fermentation processes are used to sustainably produce chemicals and as such contribute to the transition to a circular economy. The maximum theoretical yield of a conversion can only be approached if all electrons present in the substrate end up in the product. Control over the electrons is therefore crucial. However, electron transfer via redox cofactors results in a diffuse distribution of electrons over metabolism. To overcome this challenge, we propose to apply non-canonical redox cofactors (NRCs) in metabolic networks: cofactors that channel electrons exclusively from substrate to product, forming orthogonal circuits for electron transfer.

Subject

Biotechnology
Metabolic Engineering
Microbiology

To reference this document use:

http://resolver.tudelft.nl/uuid:6f3413d4-f813-4680-8e0e-1c21451caf26

DOI

https://doi.org/10.1016/j.isci.2020.101471

ISSN

2589-0042

Source

iScience, 23 (9)

Part of collection

Institutional Repository