Additively manufactured scaffolds for bone tissue engineering and the prediction of their mechanical behavior

Additively manufactured scaffolds for bone tissue engineering and the prediction of their mechanical behavior: A review

Zhang, X.Y. (Tsinghua University)
Fang, G (Tsinghua University; State Key Laboratory of Tribology)
Zhou, J. (TU Delft Biomaterials & Tissue Biomechanics)

2017

Additive manufacturing (AM), nowadays commonly known as 3D printing, is a revolutionary materials processing technology, particularly suitable for the production of low-volume parts with high shape complexities and often with multiple functions. As such, it holds great promise for the fabrication of patient-specific implants. In recent years, remarkable progress has been made in implementing AM in the bio-fabrication field. This paper presents an overview on the state-of-the-art AM technology for bone tissue engineering (BTE) scaffolds, with a particular focus on the AM scaffolds made of metallic biomaterials. It starts with a brief description of architecture design strategies to meet the biological and mechanical property requirements of scaffolds. Then, it summarizes the working principles, advantages and limitations of each of AM methods suitable for creating porous structures and manufacturing scaffolds from powdered materials. It elaborates on the finite-element (FE) analysis applied to predict the mechanical behavior of AM scaffolds, as well as the effect of the architectural design of porous structure on its mechanical properties. The review ends up with the authors’ view on the current challenges and further research directions.

additive manufacturing
scaffold
biomaterial
geometric design
mechanical property
finite element modeling
OA-Fund TU Delft

http://resolver.tudelft.nl/uuid:8c410997-4075-44a1-83fb-ac32560b4d22

https://doi.org/10.3390/ma10010050

1996-1944

Materials, 10 (1)

Institutional Repository

journal article

© 2017 X.Y. Zhang, G Fang, J. Zhou