In vitro degradation behavior and cytocompatibility of Mg–Zn–Zr alloys

In vitro degradation behavior and cytocompatibility of Mg–Zn–Zr alloys

Huan, Z.G.
Leeflang, M.A.
Zhou, J.
Fratila-Apachitei, L.E.
Duszczyk, J.

Mechanical, Maritime and Materials Engineering

Materials Science and Engineering

2010-06-09

Zinc and zirconium were selected as the alloying elements in biodegradable magnesium alloys, considering their strengthening effect and good biocompatibility. The degradation rate, hydrogen evolution, ion release, surface layer and in vitro cytotoxicity of two Mg–Zn–Zr alloys, i.e. ZK30 and ZK60, and a WE-type alloy (Mg–Y–RE–Zr) were investigated by means of longterm static immersion testing in Hank’s solution, non-static immersion testing in Hank’s solution and cell-material interaction analysis. It was found that, among these three magnesium alloys, ZK30 had the lowest degradation rate and the least hydrogen evolution. A magnesium calcium phosphate layer was formed on the surface of ZK30 sample during non-static immersion and its degradation caused minute changes in the ion concentrations and pH value of Hank’s solution. In addition, the ZK30 alloy showed insignificant cytotoxicity against bone marrow stromal cells as compared with biocompatible hydroxyapatite (HA) and the WE-type alloy. After prolonged incubation for 7 days, a stimulatory effect on cell proliferation was observed. The results of the present study suggested that ZK30 could be a promising material for biodegradable orthopedic implants and worth further investigation to evaluate its in vitro and in vivo degradation behavior.

http://resolver.tudelft.nl/uuid:8c913198-d9f8-4891-a0a2-9cff0f7cd00e

https://doi.org/10.1007/s10856-010-4111-8

Springer

0957-4530

Journal of Materials Science in Medicine, 21 (9), 2010

Institutional Repository

journal article

(c) 2010 The Author(s)