Photoenzymatic epoxidation of styrenes

Journal article (2019)

Authors

M.M.C.H. van Schie BT/Biocatalysis - AS
C.E. Paul Wageningen University & Research
I.W.C.E. Arends Universiteit Utrecht
F. Hollmann BT/Biocatalysis - AS
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2019 M.M.C.H. van Schie, C.E. Paul, I.W.C.E. Arends, F. Hollmann
DOI: https://doi.org/10.1039/c8cc08149b
More Info
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Published Date

2019

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract


Two-component-diffusible-flavomonooxygenases are versatile biocatalysts for selective epoxidation-, hydroxylation- or halogenation reactions. Their complicated molecular architecture can be simplified using photochemical regeneration of the catalytically active, reduced FADH
2
prosthetic group. In this contribution we provide the proof-of-concept and characterization for the direct regeneration of the styrene monooxygenase from Pseudomonas.