Title
Extrusion-based 3D printing of biodegradable porous iron for bone substitution
Author
Putra, N.E. (TU Delft Biomaterials & Tissue Biomechanics) 
Contributor
Zadpoor, A.A. (promotor)
Zhou, J. (promotor)
Apachitei, I. (copromotor)
Degree granting institution
Delft University of Technology
Date
2023-03-14
Abstract
The treatment of large bone injuries continues to be challenging partially due to the limited quantity and quality of bone-replacing materials. Iron (Fe) and its alloys have been developed as a group of load-bearing biomaterials. Recent advances in additive manufacturing (AM) have enhanced the potential of Fe-based biomaterials as biodegradable bone substitutes. Firstly, AM Fe-based implants can now be personalized to exactly match the geometry of bony defects. Secondly, AM Fe-based implants with macro- and micro-scale porosities can mimic the mechanical properties of the native bony tissue. The mechanical properties can also be tuned to sustain over the biodegradation period until the new bone tissue takes over their biomechanical function. Finally, AM offers a pathway for in situ or ex situ alloying as well as for other types of multi-material printing to achieve multiple functionalities, such as paramagnetic properties, high rates of biodegradation, and, most importantly, bioactivity (e.g., to induce the osteogenic differentiation of stem cells or to ward off implant-associated infections). This thesis contributes to designing biodegradable Fe-based scaffolds material configurations and developing associated fabrication technology with a focus placed on achieving an appropriate biodegradation rate, paramagnetic behavior, mimicking trabecular bone mechanical properties, and osteogenic all at once.
Subject
extrusion-based 3D printing
multi-material additive manufacturing
iiron
iron-manganese alloy
iron-akermanite composite
iron-manganese-akermanite composite
Biodegradable
porous
biomaterial
scaffolds
bone tissue engineering
To reference this document use:
https://doi.org/10.4233/uuid:a4d2f3d3-74bc-4dcd-9e5a-71deb5f74a38
ISBN
978-94-6384-416-1
Embargo date
2023-04-30
Part of collection
Institutional Repository
Document type
doctoral thesis
Rights
© 2023 N.E. Putra