Print Email Facebook Twitter Protein detection on biotin-derivatized polyallylamine by optical microring resonators Title Protein detection on biotin-derivatized polyallylamine by optical microring resonators Author Ullien, D. Harmsma, P.J. Abdulla, S.M.C. De Boer, B.M. Bosma, D. Sudhölter, E.J.R. De Smet, L.C.P.M. Jager, W.F. Faculty Applied Sciences Department ChemE/Chemical Engineering Date 2014-06-27 Abstract Silicon optical microring resonators (MRRs) are sensitive devices that can be used for biosensing. We present a novel biosensing platform based on the application of polyelectrolyte (PE) layers on such MRRs. The top PE layer was covalently labeled with biotin to ensure binding sites for antibodies via a streptavidin-biotin binding scheme. Monitoring the shift in the microring resonance wavelength allows real-time, highly sensitive detection of the biomolecular interaction. Subject sensorsbiological sensing and sensorsoptical sensing and sensors To reference this document use: http://resolver.tudelft.nl/uuid:a601bc26-c5b4-4edb-8a3f-efb4853c2bbc DOI https://doi.org/10.1364/OE.22.016585 Publisher Optical Society of America ISSN 1094-4087 Source http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-22-13-16585 Source Optics Express, 22 (13), 2014 Part of collection Institutional Repository Document type journal article Rights © 2014 Optical Society of America Files PDF Ullien_2014.pdf 1.55 MB Close viewer /islandora/object/uuid:a601bc26-c5b4-4edb-8a3f-efb4853c2bbc/datastream/OBJ/view