Protein detection on biotin-derivatized polyallylamine by optical microring resonators

Journal article (2014)
Department
ChemE/Chemical Engineering (AS) (TU Delft)
Copyright: © 2014 Optical Society of America
DOI: https://doi.org/doi:10.1364/OE.22.016585
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Published Date

27-06-2014

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Source:

Optics Express, 22 (13), 2014

Faculty

Applied Sciences

Department

ChemE/Chemical Engineering

Abstract

Silicon optical microring resonators (MRRs) are sensitive devices that can be used for biosensing. We present a novel biosensing platform based on the application of polyelectrolyte (PE) layers on such MRRs. The top PE layer was covalently labeled with biotin to ensure binding sites for antibodies via a streptavidin-biotin binding scheme. Monitoring the shift in the microring resonance wavelength allows real-time, highly sensitive detection of the biomolecular interaction.

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