Timing of objectively-collected physical activity in relation to body weight and metabolic health in sedentary older people

Timing of objectively-collected physical activity in relation to body weight and metabolic health in sedentary older people: a cross-sectional and prospective analysis

Albalak, Gali (Leiden University Medical Center)
Stijntjes, M. (TU Delft Support Biomechanical Engineering; Leiden University Medical Center)
Wijsman, Carolien A. (Leiden University Medical Center)
Slagboom, P. Eline (Leiden University Medical Center; Max Planck Institute for Biology of Ageing)
van der Ouderaa, Frans J. (Leiden University Medical Center)
Mooijaart, Simon P. (Leiden University Medical Center)
van Heemst, Diana (Leiden University Medical Center)
Noordam, Raymond (Leiden University Medical Center)

2022

Background: Little is known about the impact of timing as opposed to frequency and intensity of daily physical activity on metabolic health. Therefore, we assessed the association between accelerometery-based daily timing of physical activity and measures of metabolic health in sedentary older people. Methods: Hourly mean physical activity derived from wrist-worn accelerometers over a 6-day period was collected at baseline and after 3 months in sedentary participants from the Active and Healthy Ageing study. A principal component analysis (PCA) was performed to reduce the number of dimensions (e.g. define periods instead of separate hours) of hourly physical activity at baseline and change during follow-up. Cross-sectionally, a multivariable-adjusted linear regression analysis was used to associate the principal components, particularly correlated with increased physical activity in data-driven periods during the day, with body mass index (BMI), fasting glucose and insulin, HbA1c and the homeostatic model assessment for insulin resistance (HOMA-IR). For the longitudinal analyses, we calculated the hourly changes in physical activity and change in metabolic health after follow-up. Results: We included 207 individuals (61.4% male, mean age: 64.8 [SD 2.9], mean BMI: 28.9 [4.7]). Higher physical activity in the early morning was associated with lower fasting glucose (−2.22%, 95% CI: −4.19, −0.40), fasting insulin (−13.54%, 95%CI: −23.49, −4.39), and HOMA-IR (−16.07%, 95%CI: −27.63, −5.65). Higher physical activity in the late afternoon to evening was associated with lower BMI (−2.84%, 95% CI: −4.92, −0.70). Higher physical activity at night was associated with higher BMI (2.86%, 95% CI: 0.90, 4.78), fasting glucose (2.57%, 95% CI: 0.70, 4.30), and HbA1c (2.37%, 95% CI: 1.00, 3.82). Similar results were present in the prospective analysis. Conclusion: Specific physical activity timing patterns were associated with more beneficial metabolic health, suggesting particular time-dependent physical activity interventions might maximise health benefits.

http://resolver.tudelft.nl/uuid:a67c2d7e-97ee-492c-adca-db32d6fb6592

https://doi.org/10.1038/s41366-021-01018-7

2023-07-01

0307-0565

International Journal of Obesity, 46 (3), 515-522

Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Institutional Repository

journal article

© 2022 Gali Albalak, M. Stijntjes, Carolien A. Wijsman, P. Eline Slagboom, Frans J. van der Ouderaa, Simon P. Mooijaart, Diana van Heemst, Raymond Noordam