Controlled metal crumpling as an alternative to folding for the fabrication of nanopatterned meta-biomaterials

Ganjian, M.; Janbaz, S.; van Manen, T.; Tümer, N.; Modaresifar, K.; Minneboo, M.B.; Fratila-Apachitei, E.L.; Zadpoor, A.A.

doi:10.1016/j.matdes.2022.110844

Controlled metal crumpling as an alternative to folding for the fabrication of nanopatterned meta-biomaterials

Title

Controlled metal crumpling as an alternative to folding for the fabrication of nanopatterned meta-biomaterials

Author

Ganjian, M. (TU Delft Biomaterials & Tissue Biomechanics)
Janbaz, S. (TU Delft Biomaterials & Tissue Biomechanics; Universiteit van Amsterdam)
van Manen, T. (TU Delft Support Biomechanical Engineering)
Tümer, N. (TU Delft Biomaterials & Tissue Biomechanics)
Modaresifar, K. (TU Delft Biomaterials & Tissue Biomechanics)
Minneboo, M.B. (TU Delft Biomaterials & Tissue Biomechanics)
Fratila-Apachitei, E.L. (TU Delft Biomaterials & Tissue Biomechanics)
Zadpoor, A.A. (TU Delft Biomaterials & Tissue Biomechanics)

Date

2022

Abstract

We designed and fabricated a simple setup for the controlled crumpling of nanopatterned, surface-porous flat metallic sheets for the fabrication of volume-porous biomaterials and showed that crumpling can be considered as an efficient alternative to origami-inspired folding. Before crumpling, laser cutting was used to introduce pores to the sheets. We then fabricated titanium (Ti) nanopatterns through reactive ion etching on the polished Ti sheets. Thereafter, nanopatterned porous Ti sheets were crumpled at two deformation velocities (i.e., 2 and 100 mm/min). The compression tests of the scaffolds indicated that the elastic modulus of the specimens vary in the range of 11.8–13.9 MPa. Micro-computed tomography scans and computational simulations of crumpled scaffolds were performed to study the morphological properties of the resulting meta-biomaterials. The porosity and pore size of the scaffolds remained within the range of those reported for trabecular bone. Finally, the in vitro cell preosteoblasts culture demonstrated the cytocompatibility of the nanopatterned scaffolds. Moreover, the aspect ratio of the cells residing on the nanopatterned surfaces was found to be significantly higher than those cultured on the control scaffolds, indicating that the nanopatterned surface may have a higher potential for inducing the osteogenic differentiation of the preosteoblasts.

Subject

2D-to-3D transition
Bone scaffolds
Cell-nanopattern interactions
Crumpling
Orthopedic biomaterials

To reference this document use:

http://resolver.tudelft.nl/uuid:acc97e90-3ac9-45d6-8f0f-83e10328c441

DOI

https://doi.org/10.1016/j.matdes.2022.110844

ISSN

0264-1275

Source

Materials & Design, 220

Part of collection

Institutional Repository