Photoelectroenzymatic Oxyfunctionalization on Flavin-Hybridized Carbon Nanotube Electrode Platform

Photoelectroenzymatic Oxyfunctionalization on Flavin-Hybridized Carbon Nanotube Electrode Platform

Choi, Da Som (Korea Advanced Institute of Science and Technology)
Ni, Y. (TU Delft BT/Biocatalysis)
Fernandez Fueyo, E. (TU Delft BT/Biocatalysis)
Lee, Minah (Korea Advanced Institute of Science and Technology)
Hollmann, F. (TU Delft BT/Biocatalysis)
Park, Chan Beum (Korea Advanced Institute of Science and Technology)

2017-03-03

Peroxygenases are very promising catalysts for oxyfunctionalization reactions. Their practical applicability, however, is hampered by their sensitivity against the oxidant (H₂O₂), therefore necessitating in situ generation of H₂O₂. Here, we report a photoelectrochemical approach to provide peroxygenases with suitable amounts of H₂O₂ while reducing the electrochemical overpotential needed for the reduction of molecular oxygen to H₂O₂. When tethered on single-walled carbon nanotubes (SWNTs) under illumination, flavins allowed for a marked anodic shift of the oxygen reduction potential in comparison to pristine SWNT and/or nonilluminated electrodes. This flavin-SWNT-based photoelectrochemical platform enabled peroxygenases-catalyzed, selective hydroxylation reactions.

flavins
heme proteins
oxyfunctionalization
peroxygenases
photoelectrochemistry

http://resolver.tudelft.nl/uuid:ad754c57-2730-438c-8d02-98294fa70eb1

https://doi.org/10.1021/acscatal.6b03453

2018-01-23

2155-5435

ACS Catalysis, 7 (3), 1563-1567

Accepted Author Manuscript

Institutional Repository

journal article

© 2017 Da Som Choi, Y. Ni, E. Fernandez Fueyo, Minah Lee, F. Hollmann, Chan Beum Park