Print Email Facebook Twitter Injectable pH-responsive Ureido-Pyrimidinone (UPy) hydrogel as drug carrier for epicardial activation Title Injectable pH-responsive Ureido-Pyrimidinone (UPy) hydrogel as drug carrier for epicardial activation Author Lauta, Francesca (TU Delft Mechanical, Maritime and Materials Engineering; TU Delft Biomaterials & Tissue Biomechanics; Leiden University Medical Center) Contributor Fratila-Apachitei, E.L. (mentor) Zadpoor, A.A. (graduation committee) Goumans, M-J TH (graduation committee) Dronkers, Esther (graduation committee) Carroll, E.C.M. (graduation committee) Degree granting institution Delft University of Technology Programme Mechanical Engineering Date 2019-04-29 Abstract The presence of a stem cell source in the epicardium that can be stimulated by exogenous delivery of transforming growth factor-β (TGF-β) and migrate towards the myocardium can represent a new approach to achieve cardiac repair following myocardial infarction. However, injection of drugs always requires use of carriers which help stabilize the compound in the harsh and dynamic environment of the heart. To this extent, pH-responsive drug delivery systems represent an enthralling approach to ensure minimal invasiveness, instantaneous responsiveness, and targeted delivery of the incorporated compound. In this in vitro study we aimed to validate an Ureidopyrimidinone-based supramolecular hydrogel as TGF-β carrier for epicardial activation. The results demonstrated the capacity of the hydrogel to respond to pH changes and deliver the growth factor, which retained its ability to activate its signalling pathway and stimulate treated cells. Subject EpicardiumMyocardial InfarctionCardiac RepairDrug Delivery SystemTGF-βHydrogelpH-responsive To reference this document use: http://resolver.tudelft.nl/uuid:c815354a-f62c-478d-a1ab-7c774bee7305 Embargo date 2022-04-30 Part of collection Student theses Document type master thesis Rights © 2019 Francesca Lauta Files PDF Thesis_FCLauta.pdf 1.81 MB Close viewer /islandora/object/uuid:c815354a-f62c-478d-a1ab-7c774bee7305/datastream/OBJ/view