Print Email Facebook Twitter Evolutionary dynamics in the fungal polarization network, a mechanistic perspective Title Evolutionary dynamics in the fungal polarization network, a mechanistic perspective Author Diepeveen, E.T. (TU Delft BN/Liedewij Laan Lab; Kavli institute of nanoscience Delft) Iñigo de la Cruz, L.M. (TU Delft BN/Liedewij Laan Lab; Kavli institute of nanoscience Delft) Laan, L. (TU Delft BN/Liedewij Laan Lab; Kavli institute of nanoscience Delft) Date 2017-08-01 Abstract Polarity establishment underlies proper cell cycle completion across virtually all organisms. Much progress has been made in generating an understanding of the structural and functional components of this process, especially in model species. Here we focus on the evolutionary dynamics of the fungal polarization protein network in order to determine general components and mechanistic principles, species- or lineage-specific adaptations and the evolvability of the network. The currently available genomic and proteomic screens in a variety of fungal species have shown three main characteristics: (1) certain proteins, processes and functions are conserved throughout the fungal clade; (2) orthologous functions can never be assumed, as various cases have been observed of homologous loci with dissimilar functions; (3) species have, typically, various species- or lineage-specific proteins incorporated in their polarization network. Further large-scale comparative and experimental studies, including those on non-model species representing the great fungal diversity, are needed to gain a better understanding of the evolutionary dynamics and generalities of the polarization network in fungi. Subject AdaptationCell polarityEvolutionEvolutionary conservationFungiProtein network To reference this document use: http://resolver.tudelft.nl/uuid:d30d2d32-ba36-478a-8ff2-d7a78055b926 DOI https://doi.org/10.1007/s12551-017-0286-2 ISSN 1867-2450 Source Biophysical Reviews, 9 (4), 375-387 Part of collection Institutional Repository Document type review Rights © 2017 E.T. Diepeveen, L.M. Iñigo de la Cruz, L. Laan Files PDF 10.1007_s12551_017_0286_2.pdf 951.5 KB Close viewer /islandora/object/uuid:d30d2d32-ba36-478a-8ff2-d7a78055b926/datastream/OBJ/view