Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second

Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second

Wu, Min (Erasmus MC)
Springeling, Geert (Erasmus MC)
Lovrak, M. (TU Delft ChemE/Advanced Soft Matter)
Mastik, Frits (Erasmus MC)
Iskander-Rizk, Sophinese (Erasmus MC)
Wang, Tianshi (Erasmus MC)
Van Beusekom, Heleen M.M. (Erasmus MC)
van der Steen, A.F.W. (TU Delft ImPhys/Acoustical Wavefield Imaging; Erasmus MC; Chinese Academy of Sciences)
van Soest, G. (Erasmus MC)

2017-02-01

Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arteries in vivo, at a clinically useful frame rate of 20 s⁻¹. We confirmed image contrast for atherosclerotic plaque in human samples ex vivo. The system is on a mobile platform and provides real-time data visualization during acquisition. We achieved an IVPA signal-to-noise ratio of 20 dB. These data show that clinical translation of IVPA is possible in principle.

Imaging systems
Photoacoustic imaging

http://resolver.tudelft.nl/uuid:e31f5f47-fca7-42de-810b-c8f2dd9c7516

https://doi.org/10.1364/BOE.8.000943

2156-7085

Biomedical Optics Express, 8 (2), 943-953

Institutional Repository

journal article

© 2017 Min Wu, Geert Springeling, M. Lovrak, Frits Mastik, Sophinese Iskander-Rizk, Tianshi Wang, Heleen M.M. Van Beusekom, A.F.W. van der Steen, G. van Soest