Print Email Facebook Twitter Molecular characterization of the stress network in individuals at risk for schizophrenia Title Molecular characterization of the stress network in individuals at risk for schizophrenia Author Meijer, Mandy (Leiden University Medical Center; Radboud University Medical Center) Keo, D.L. (TU Delft Pattern Recognition and Bioinformatics) van Leeuwen, Judith M.C. (University Medical Center Utrecht; Radboud University Medical Center) Dzyubachyk, Oleh (Leiden University Medical Center) Meijer, Onno C. (Leiden University Medical Center) Vinkers, Christiaan H. (Amsterdam UMC) Mahfouz, A.M.E.T.A. (TU Delft Pattern Recognition and Bioinformatics; Leiden Computational Biology Center; Leiden University Medical Center) Date 2021 Abstract The biological mechanisms underlying inter-individual differences in human stress reactivity remain poorly understood. We aimed to identify the molecular underpinning of aberrant neural stress sensitivity in individuals at risk for schizophrenia. Linking mRNA expression data from the Allen Human Brain Atlas to task-based fMRI revealed 201 differentially expressed genes in cortex-specific brain regions differentially activated by stress in individuals with low (healthy siblings of schizophrenia patients) or high (healthy controls) stress sensitivity. These genes are associated with stress-related psychiatric disorders (e.g. schizophrenia and anxiety) and include markers for specific neuronal populations (e.g. ADCYAP1, GABRB1, SSTR1, and TNFRSF12A), neurotransmitter receptors (e.g. GRIN3A, SSTR1, GABRB1, and HTR1E), and signaling factors that interact with the corticosteroid receptor and hypothalamic-pituitary-adrenal axis (e.g. ADCYAP1, IGSF11, and PKIA). Overall, the identified genes potentially underlie altered stress reactivity in individuals at risk for schizophrenia and other psychiatric disorders and play a role in mounting an adaptive stress response in at-risk individuals, making them potentially druggable targets for stress-related diseases. Subject Molecular correlatesStress networkStress reactivityStress sensitivityStress-related diseases To reference this document use: http://resolver.tudelft.nl/uuid:f860bee3-6578-405c-ad7e-0f28b6144f5e DOI https://doi.org/10.1016/j.ynstr.2021.100307 Source Neurobiology of Stress, 14 Part of collection Institutional Repository Document type journal article Rights © 2021 Mandy Meijer, D.L. Keo, Judith M.C. van Leeuwen, Oleh Dzyubachyk, Onno C. Meijer, Christiaan H. Vinkers, A.M.E.T.A. Mahfouz Files PDF 1_s2.0_S2352289521000151_main.pdf 6.78 MB PDF 1_s2.0_S2352289521000151_main.pdf 6.78 MB Close viewer /islandora/object/uuid:f860bee3-6578-405c-ad7e-0f28b6144f5e/datastream/OBJ1/view