Print Email Facebook Twitter Validation of a New Transcutaneous tcPO2/tcPCO2Sensor with an Optical Oxygen Measurement in Preterm Neonates Title Validation of a New Transcutaneous tcPO2/tcPCO2Sensor with an Optical Oxygen Measurement in Preterm Neonates Author Van Weteringen, Willem (Erasmus MC) Van Essen, Tanja (Erasmus MC) Gangaram-Panday, Norani H. (Erasmus MC) Goos, T.G. (TU Delft Medical Instruments & Bio-Inspired Technology; Erasmus MC) De Jonge, Rogier C.J. (Erasmus MC) Reiss, Irwin K.M. (Erasmus MC) Date 2021 Abstract Introduction: Traditional transcutaneous oxygen (tcPO2) measurements are affected by measurement drift, limiting accuracy and usability. The new potentially drift-free oxygen fluorescence quenching technique has been combined in a single sensor with conventional transcutaneous carbon dioxide (tcPCO2) monitoring. This study aimed to validate optical tcPO2 and conventional tcPCO2 against arterial blood gas samples in preterm neonates and determine measurement drift. Methods: In this prospective observational study, during regular care, transcutaneous measurements were paired to arterial blood gases from preterm neonates aged 24-31 weeks of gestational age (GA) with an arterial catheter. Samples were included based on stability criteria and stratified for sepsis status. Agreement was assessed using the Bland-Altman analysis. Measurement drift per hour was calculated. Results: Sixty-eight premature neonates were included {median (interquartile range [IQR]) GA of 26 4/7 [25 3/7-27 5/7] weeks}, resulting in 216 stable paired samples. Agreement of stable samples in neonates without sepsis (n = 38) and with suspected sepsis (n = 112) was acceptable for tcPO2 and good for tcPCO2. However, in stable samples of neonates with sepsis (n = 66), tcPO2 agreement (bias and 95% limits of agreement) was -32.6 (-97.0 to 31.8) mm Hg and tcPCO2 agreement was 4.2 (-10.5 to 18.9) mm Hg. The median (IQR) absolute drift values were 0.058 (0.0231-0.1013) mm Hg/h for tcPO2 and 0.30 (0.11-0.64) mm Hg/h for tcPCO2. Conclusion: The accuracy of optical tcPO2 in premature neonates was acceptable without sepsis, while electrochemically measured tcPCO2 remained accurate under all circumstances. Measurement drift was negligible for tcPO2 and highly acceptable for tcPCO2. Subject NeonateSensorTranscutaneous carbon dioxideTranscutaneous measurementsTranscutaneous oxygen To reference this document use: http://resolver.tudelft.nl/uuid:1d5b20b1-8a0e-4a15-8101-557c7b9d3706 DOI https://doi.org/10.1159/000510659 ISSN 1661-7800 Source Neonatology, 117 (5), 628-636 Part of collection Institutional Repository Document type journal article Rights © 2021 Willem Van Weteringen, Tanja Van Essen, Norani H. Gangaram-Panday, T.G. Goos, Rogier C.J. De Jonge, Irwin K.M. Reiss Files PDF 510659.pdf 485.83 KB Close viewer /islandora/object/uuid:1d5b20b1-8a0e-4a15-8101-557c7b9d3706/datastream/OBJ/view