Building blocks for a European Organ-on-Chip roadmap

Journal article (2019)

Authors

Massimo Mastrangeli Electronic Components, Technology and Materials - EEMCS
Sylvie Millet CEA Grenoble
Berend J. van Meer Leiden University Medical Center
Ignacio Ochoa University of Zaragoza
Christine L. Mummery Leiden University Medical Center
Peter Loskill Fraunhofer IGB
Madalena Cipriano Fraunhofer IGB
Luis Fernandez University of Zaragoza
M.W.M. Graef EEMCS Relations & Valorisation
Xavier Gidrol CEA Grenoble
Research Group
Electronic Components, Technology and Materials (EEMCS) (TU Delft)
Copyright: © 2019 Massimo Mastrangeli, Sylvie Millet, Christine Mummery, Peter Loskill, Dries Braeken, Wolfgang Eberle, Madalena Cipriano, Luis Fernandez, M.W.M. Graef, Xavier Gidrol, Nathalie Picollet-D'Hahan, Berend van Meer, Ignacio Ochoa, Mieke Schutte, Janny van den Eijnden-van Raaij
DOI: https://doi.org/10.14573/altex.1905221
More Info
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Published Date

19-07-2019

Language

English

Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Microelectronics

Research Group

Electronic Components, Technology and Materials

Abstract

This paper summarizes the outcome of the Organ-on-Chip (OoC) ORCHID Strategy workshop (Leiden, the Netherlands, 17 January 2019) intended to establish a European OoC roadmap through expert discussions, conclusions and recommendations. The workshop identified six specific building blocks for the OoC roadmap: (1) application, (2) specification, (3) qualification, (4) standardization, (5) production and upscaling, and (6) adoption. Complementary aspects relating to ethics and communication were also addressed. Priorities, methods and targets for the roadmap were proposed for each building block. General consensus was reached on the potential contribution of the newly founded European Organ-on-Chip Society (EUROoCS), which could facilitate deployment of each block. EUROoCS would ideally initiate and catalyze dialogue between OoC developers, end users and regulators. The dialogue should address qualification, open technology platforms, standardization and implementation of OoC technology, as well as ethical aspects of human tissue mimics, training the next generation of OoC researchers, dissemination and communication.