Print Email Facebook Twitter Tissue characterization with depthresolved attenuation coefficient and backscatter term in intravascular optical coherence tomography images Title Tissue characterization with depthresolved attenuation coefficient and backscatter term in intravascular optical coherence tomography images Author Liu, Shengnan (Leiden University Medical Center) Sotomi, Yohei (Amsterdam UMC) Eggermont, Jeroen (Leiden University Medical Center) Nakazawa, Gaku (Tokai University) Torii, Sho (Tokai University) Ijichi, Takeshi (Tokai University) Onuma, Yoshinobu (Cardialysis; Erasmus MC) Serruys, Patrick W. (Imperial College London) Lelieveldt, B.P.F. (TU Delft Pattern Recognition and Bioinformatics; Leiden University Medical Center) Dijkstra, J. (Leiden University Medical Center) Date 2017 Abstract An important application of intravascular optical coherence tomography (IVOCT) for atherosclerotic tissue analysis is using it to estimate attenuation and backscatter coefficients. This work aims at exploring the potential of the attenuation coefficient, a proposed backscatter term, and image intensities in distinguishing different atherosclerotic tissue types with a robust implementation of depth-resolved (DR) approach. Therefore, the DR model is introduced to estimate the attenuation coefficient and further extended to estimate the backscatter-related term in IVOCT images, such that values can be estimated per pixel without predefining any delineation for the estimation. In order to exclude noisy regions with a weak signal, an automated algorithm is implemented to determine the cut-off border in IVOCT images. The attenuation coefficient, backscatter term, and the image intensity are further analyzed in regions of interest, which have been delineated referring to their pathology counterparts. Local statistical values were reported and their distributions were further compared with a two-sample t -test to evaluate the potential for distinguishing six types of tissues. Results show that the IVOCT intensity, DR attenuation coefficient, and backscatter term extracted with the reported implementation are complementary to each other on characterizing six tissue types: mixed, calcification, fibrous, lipid-rich, macrophages, and necrotic core. Subject attenuation coefficientbackscatter termcalcificationdepth-resolvedfibrousintravascular optical coherence tomographylipid necrotic coremacrophages To reference this document use: http://resolver.tudelft.nl/uuid:c8a45a09-a07f-468d-9f1f-4f4e33ebce12 DOI https://doi.org/10.1117/1.JBO.22.9.096004 ISSN 1083-3668 Source Journal of Biomedical Optics, 22 (9), 1-16 Part of collection Institutional Repository Document type journal article Rights © 2017 Shengnan Liu, Yohei Sotomi, Jeroen Eggermont, Gaku Nakazawa, Sho Torii, Takeshi Ijichi, Yoshinobu Onuma, Patrick W. Serruys, B.P.F. Lelieveldt, J. Dijkstra Files PDF 44920684_096004.pdf 5.78 MB Close viewer /islandora/object/uuid:c8a45a09-a07f-468d-9f1f-4f4e33ebce12/datastream/OBJ/view