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Simoes dos Santos, D. (author), Ossenkoppele, B.W. (author), Hopf, Y.M. (author), Soozande, Mehdi (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author)
Objective: Described here is the development of an ultrasound matrix transducer prototype for high-frame-rate 3-D intra-cardiac echocardiography. Methods: The matrix array consists of 16 × 18 lead zirconate titanate elements with a pitch of 160 µm × 160 µm built on top of an application-specific integrated circuit that generates transmission...
journal article 2024
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Kortenbout, A.J. (author), Costerus, Sophie (author), Dudink, Jeroen (author), de Jong, N. (author), de Graaff, Jurgen C. (author), Vos, H.J. (author), Bosch, Johan G. (author)
Objective: Post-operative brain injury in neonates may result from disturbed cerebral perfusion, but accurate peri-operative monitoring is lacking. High-frame-rate (HFR) cerebral ultrasound could visualize and quantify flow in all detectable vessels using spectral Doppler; however, automated quantification in small vessels is challenging...
journal article 2024
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Guo, P. (author), Fool, F. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), de Jong, N. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author)
This article presents a low-power and small-area transceiver application-specific integrated circuit (ASIC) for 3-D trans-fontanelle ultrasonography. A novel micro-beamforming receiver architecture that employs current-mode summation and boxcar integration is used to realize delay-and-sum on an N -element sub-array using N× fewer capacitive...
journal article 2023
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Wu, X. (author), Saaid, Hicham (author), Voorneveld, J.D. (author), Claessens, Tom (author), Westenberg, Jos J.M. (author), de Jong, N. (author), Bosch, Johan G. (author), Kenjeres, S. (author)
Purpose: Intraventricular blood flow dynamics are associated with cardiac function. Accurate, noninvasive, and easy assessments of hemodynamic quantities (such as velocity, vortex, and pressure) could be an important addition to the clinical diagnosis and treatment of heart diseases. However, the complex time-varying flow brings many...
journal article 2023
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Caenen, Annette (author), Keijzer, Lana (author), Bézy, Stéphanie (author), Duchenne, Jürgen (author), Orlowska, Marta (author), van der Steen, A.F.W. (author), de Jong, N. (author), Bosch, Johan G. (author), Voigt, Jens Uwe (author), D’hooge, Jan (author), Vos, H.J. (author)
Ultrasound-based shear wave elastography is a promising technique to non-invasively assess the dynamic stiffness variations of the heart. The technique is based on tracking the propagation of acoustically induced shear waves in the myocardium of which the propagation speed is linked to tissue stiffness. This measurement is repeated multiple...
journal article 2023
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Guo, P. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, J. G. (author), de Jong, N. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author)
This paper presents a pitch-matched transceiver ASIC integrated with a 2-D transducer array for a wearable ultrasound device for transfontanelle ultrasonography. The ASIC combines 8-fold multiplexing, 4-channel micro-beamforming (μ BF) and sub-array-level digitization to achieve a 128-fold channel-count reduction. The μ BF is based on passive...
conference paper 2023
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Spiekhout, Sander (author), Voorneveld, J.D. (author), Van Elburg, Benjamin (author), Renaud, G.G.J. (author), Segers, Tim (author), Lajoinie, Guillaume P.R. (author), Versluis, Michel (author), Verweij, M.D. (author), de Jong, N. (author), Bosch, Johannes G. (author)
Ultrasound (US) contrast agents consist of microbubbles ranging from 1 to 10 μm in size. The acoustical response of individual microbubbles can be studied with high-frame-rate optics or an "acoustical camera"(AC). The AC measures the relative microbubble oscillation while the optical camera measures the absolute oscillation. In this article,...
journal article 2022
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Hopf, Y.M. (author), Ossenkoppele, Boudewine W. (author), Soozande, Mehdi (author), Noothout, E.C. (author), Chang, Z.Y. (author), Chen, Chao (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)
In this article, an application-specific integrated circuit (ASIC) for 3-D, high-frame-rate ultrasound imaging probes is presented. The design is the first to combine element-level, high-voltage (HV) transmitters and analog front-ends, subarray beamforming, and in-probe digitization in a scalable fashion for catheter-based probes. The...
journal article 2022
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Soozande, Mehdi (author), Ossenkoppele, B.W. (author), Hopf, Y.M. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author), Vos, H.J. (author), Bosch, Johan G. (author)
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is normally treated by RF ablation. Intracardiac echography (ICE) is widely employed during RF ablation procedures to guide the electrophysiologist in navigating the ablation catheter, although only 2-D probes are currently clinically used. A 3-D ICE catheter would not only...
journal article 2022
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Guo, P. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), de Jong, N. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author)
This article presents a compact analog front-end (AFE) circuit for ultrasound receivers with linear-in-dB continuous gain control for time-gain compensation (TGC). The AFE consists of two variable-gain stages, both of which employ a novel complementary current-steering network (CCSN) as the interpolator to realize continuously variable gain....
journal article 2022
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Guo, P. (author), Fool, F. (author), Noothout, E.C. (author), Chang, Z.Y. (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)
The integration of 2D ultrasonic transducer arrays and pitch-matched ASICs has enabled the realization of various 3D ultrasound imaging devices in recent years [1]-[3]. As applications such as 3D intravascular ultrasonography, intra-cardiac echocardiography, and trans-fontanelle ultrasonography call for miniaturization and improved spatial...
conference paper 2022
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Simoes dos Santos, D. (author), Fool, F. (author), Mozaffarzadeh, M. (author), Shabanimotlagh, M. (author), Noothout, E.C. (author), Kim, T. (author), Rozsa, N.N.M. (author), Vos, H.J. (author), Bosch, Johan G. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author)
High frame rate three-dimensional (3D) ultrasound imaging would offer excellent possibilities for the accurate assessment of carotid artery diseases. This calls for a matrix transducer with a large aperture and a vast number of elements. Such a matrix transducer should be interfaced with an application-specific integrated circuit (ASIC) for...
journal article 2022
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Hopf, Y.M. (author), Ossenkoppele, B.W. (author), Soozande, M. (author), Noothout, E.C. (author), Chang, Z.Y. (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)
In this letter, a compact high-voltage (HV) transmit circuit for dense 2-D transducer arrays used in 3-D ultrasonic imaging systems is presented. Stringent area requirements are addressed by a unipolar pulser with embedded transmit/receive switch. Combined with a capacitive HV level shifter, it forms the ultrasonic HV...
journal article 2022
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Colas, Quorentin (author), Bantignies, Claire (author), Perroteau, Marie (author), Porcher, Nicolas (author), Vassal, Steeven (author), Bosch, Johan G. (author), de Jong, N. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author)
Three-dimensional ultrasound has initially been used to address volumetric imaging for diagnostic purposes and represents the leading-edge technological orientation in both transducer and IC (integrated circuit) architecture and design. However, new applications are coming up like biomarker measurements, preoperative navigation, real time...
conference paper 2022
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Hopf, Y.M. (author), Ossenkoppele, B.W. (author), Soozande, M. (author), Noothout, E.C. (author), Chang, Z.Y. (author), Chen, C. (author), Vos, H.J. (author), Bosch, J.G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)
Intra-cardiac echography (ICE) probes (Fig. 32.2.1) are widely used in electrophysiology for their good procedure guidance and relatively safe application. ASICs are increasingly employed in these miniature probes to enhance signal quality and reduce the number of connections needed in mm-diameter catheters [1]-[5]. 3D visualization in real...
conference paper 2022
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Voorneveld, J.D. (author), Keijzer, L.B.H. (author), Strachinaru, Mihai (author), Bowen, Daniel J. (author), Mutluer, Ferit O. (author), van der Steen, A.F.W. (author), Ten Cate, Folkert (author), de Jong, N. (author), Vos, H.J. (author), Van den Bosch, Annemien E. (author), Bosch, Johan G. (author)
High-frame-rate (HFR) echo-particle image velocimetry (echoPIV) is a promising tool for measuring intracardiac blood flow dynamics. In this study, we investigate the optimal ultrasound contrast agent (UCA: SonoVue) infusion rate and acoustic output to use for HFR echoPIV (PRF = 4900 Hz) in the left ventricle (LV) of patients. Three infusion...
journal article 2021
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Kim, Taehoon (author), Fool, F. (author), Simoes dos Santos, D. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)
This paper presents an ultrasound transceiver application-specific integrated circuit (ASIC) directly integrated with an array of 12 × 80 piezoelectric transducer elements to enable next-generation ultrasound probes for 3D carotid artery imaging. The ASIC, implemented in a 0.18 µm high-voltage Bipolar-CMOS-DMOS (HV BCD) process, adopted a...
journal article 2021
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Simoes dos Santos, D. (author), Fool, F. (author), Kim, Taehoon (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author)
Over the past decades, real-time three-dimensional (3D) medical ultrasound has attracted much attention since it enables clinicians to diagnose more accurately. This calls for ultrasound matrix transducers with a large number of elements, which can be interfaced with an application-specific integrated circuit (ASIC) for data reduction. An...
conference paper 2021
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Voorneveld, J.D. (author), Saaid, H. (author), Schinkel, C.V. (author), Radeljic, Nikola (author), Lippe, Boris (author), Gijsen, F.J.H. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Claessens, Tom (author), Vos, H.J. (author), Kenjeres, S. (author), Bosch, Johan G. (author)
Left ventricular (LV) blood flow is an inherently complex time-varying 3-D phenomenon, where 2-D quantification often ignores the effect of out-of-plane motion. In this study, we describe high frame rate 4-D echocardiographic particle image velocimetry (echo-PIV) using a prototype matrix transesophageal transducer and a dynamic LV phantom for...
journal article 2020
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Mozaffarzadeh, M. (author), Soozande, M. (author), Fool, F. (author), Pertijs, M.A.P. (author), Vos, H.J. (author), Verweij, M.D. (author), Bosch, Johan G. (author), de Jong, N. (author)
Recently, we realized a prototype matrix transducer consisting of 48 rows of 80 elements on top of a tiled set of Application Specific Integrated Circuits (ASICs) implementing a row-level control connecting one transmit/receive channel to an arbitrary subset of elements per row. A fully sampled array data acquisition is implemented by a...
journal article 2020
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