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Smeets, R.M.M. (author), Keyser, U.F. (author), Wu, M.Y. (author), Dekker, N.H. (author), Dekker, C. (author)
journal article 2006
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Krishnan, S.T. (author), Moolman, M.C. (author), Van Laar, T. (author), Meyer, A.S. (author), Dekker, N.H. (author)
Background Chromosome engineering encompasses a collection of homologous recombination-based techniques that are employed to modify the genome of a model organism in a controlled fashion. Such techniques are widely used in both fundamental and industrial research to introduce multiple insertions in the same Escherichia coli strain. To date, ?...
journal article 2015
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Dekker, C. (author), Arts, A.F.M. (author)
journal article 1988
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Janssen, J.W. (author), Lemay, S.G. (author), Kouwenhoven, L.P. (author), Dekker, C. (author)
journal article 2002
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Koster, D.A. (author), Czerwinski, F. (author), Halby, L. (author), Crut, A. (author), Vekhoff, P. (author), Palle, K. (author), Arimondo, P.B. (author), Dekker, N.H. (author)
The rate of DNA supercoil removal by human topoisomerase IB (TopIB) is slowed down by the presence of the camptothecin class of antitumor drugs. By preventing religation, these drugs also prolong the lifetime of the covalent TopIB–DNA complex. Here, we use magnetic tweezers to measure the rate of supercoil removal by drugbound TopIB at a single...
journal article 2008
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Liefrink, F. (author), Scholten, A.J. (author), Dekker, C. (author), Dijkhuis, J.I. (author), Alphenaar, B.W. (author), Van Houten, H. (author), Foxon, C.T. (author)
journal article 1992
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Van Dieten, V.E.J. (author), Dekker, J.P. (author), Schoonman, J. (author)
journal article 1992
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Stein, D. (author), Kruithof, M. (author), Dekker, C. (author)
journal article 2004
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Dekker, R. (author)
“A what on a chip?” is what most people ask with disbelief when they hear for the first time of the new and very exciting research area “Organ on a Chip.” The topic has nothing to do with Science Fiction, but everything with a very surprising encounter between two completely different research fields: Microfabrication and Stem-Cell Biology! The...
journal article 2013
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LeRoy, B.J. (author), Kong, J. (author), Pahilwani, V.K. (author), Dekker, C. (author), Lemay, S.G. (author)
journal article 2005
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Moene, R. (author), Dekker, J.P. (author), Makkee, M. (author), Schoonman, J. (author), Moulijn, J.A. (author)
journal article 1994
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Eeftens, J.M. (author), Katan, A.J. (author), Kschonsak, Marc (author), Hassler, Markus (author), de Wilde, L. (author), Dief, Essam M. (author), Haering, Christian H. (author), Dekker, C. (author)
Structural maintenance of chromosomes (SMC) protein complexes, including cohesin and condensin, play key roles in the regulation of higher-order chromosome organization. Even though SMC proteins are thought to mechanistically determine the function of the complexes, their native conformations and dynamics have remained unclear. Here, we probe...
journal article 2016
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Vtyurina, N. (author), Dulin, D. (author), Docter, M.W. (author), Meyer, A.S. (author), Dekker, N.H. (author), Abbondanzieri, E. (author)
In all organisms, DNA molecules are tightly compacted into a dynamic 3D nucleoprotein complex. In bacteria, this compaction is governed by the family of nucleoid-associated proteins (NAPs). Under conditions of stress and starvation, an NAP called Dps (DNA binding protein from starved cells) becomes highly up-regulated and can massively...
journal article 2016
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Ganji, M. (author), Shaltiel, Indra A. (author), Bisht, Shveta (author), Kim, E. (author), Kalichava, A. (author), Haering, Christian H. (author), Dekker, C. (author)
It has been hypothesized that SMC protein complexes such as condensin and cohesin spatially organize chromosomes by extruding DNA into large loops. We directly visualized the formation and processive extension of DNA loops by yeast condensin in real time. Our findings constitute unambiguous evidence for loop extrusion. We observed that a...
journal article 2018
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Moolman, M.C. (author), Huang, Z. (author), Krishnan, S.T. (author), Kerssemakers, J.W.J. (author), Dekker, N.H. (author)
Background: Controlled restriction of cellular movement using microfluidics allows one to study individual cells to gain insight into aspects of their physiology and behaviour. For example, the use of micron-sized growth channels that confine individual Escherichia coli has yielded novel insights into cell growth and death. To extend this...
journal article 2013
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Dekker, J.P. (author), Van Dieten, V.E.J. (author), Schoonman, J. (author)
journal article 1992
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Dekker, R. (author), Waaijers, L. (author)
Document delivery bridges the gap between where the customer is and where the document is. Libraries have to offer user-friendly access to hybrid collections, and design and implement document delivery mechanisms from paper originals to provide a seamless integration between delivery from electronic and paper articles. Apart from improved...
journal article 2001
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Berghuis, Bojk A. (author), Dulin, David (author), Xu, Zhi Qiang (author), van Laar, T. (author), Cross, Bronwen (author), Janissen, R. (author), Jergic, Slobodan (author), Dixon, Nicholas E. (author), Depken, S.M. (author), Dekker, N.H. (author)
The bidirectional replication of a circular chromosome by many bacteria necessitates proper termination to avoid the head-on collision of the opposing replisomes. In Escherichia coli, replisome progression beyond the termination site is prevented by Tus proteins bound to asymmetric Ter sites. Structural evidence indicates that strand...
journal article 2015
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Kim, S.H. (author), Vlijm, R. (author), van der Torre, J. (author), Dalal, Y. (author), Dekker, C. (author)
Centromere-specific nucleosomes are a central feature of the kinetochore complex during mitosis, in which microtubules exert pulling and pushing forces upon the centromere. CENP-A nucleosomes have been assumed to be structurally unique, thereby providing resilience under tension relative to their H3 canonical counterparts. Here, we directly test...
journal article 2016
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Dekker, C. (author), Eidelloth, W. (author), Koch, R.H. (author)
journal article 1993
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