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Kalafut, B.S. (author), Skinner, G.M. (author), Visscher, K. (author)
To access the genetic code to be transcribed to RNA, RNA polymerases must first open a “transcription bubble” in the DNA. Structural studies suggest that the minimal model of initiation by T7 bacterophage RNA polymerase (T7 RNAP) consists of two distinct steps: initial binding, in which the T7 RNAP binds to and bends the DNA, and opening,...
conference paper 2009