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Puiman, L. (author), Almeida Benalcazar, E.F. (author), Picioreanu, C. (author), Noorman, H.J. (author), Haringa, C. (author)
In large-scale syngas fermentation, strong gradients in dissolved gas (CO, H<sub>2</sub>) concentrations are very likely to occur due to locally varying mass transfer and convection rates. Using Euler-Lagrangian CFD simulations, we analyzed these gradients in an industrial-scale external-loop gas-lift reactor (EL-GLR) for a wide range of...
journal article 2023
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Haringa, C. (author)
Euler-Lagrange CFD simulations, where the biotic phase is represented by computational particles (parcels), provide information on environmental gradients inside bioreactors from the microbial perspective. Such information is highly relevant for reactor scale-down and process optimization. One of the major challenges is the computational...
journal article 2022
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Haringa, C. (author), Deshmukh, Amit T. (author), Mudde, R.F. (author), Noorman, H.J. (author)
With reaction timescales equal to or shorter than the circulation time, the ideal mixing assumption typically does not hold for large scale bioreactors. As a consequence large scale gradients in extra-cellular conditions such as the substrate concentration exist, which may significantly impact the metabolism of micro-organisms and thereby the...
journal article 2017
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Haringa, C. (author), Tang, Wenjun (author), Deshmukh, Amit T. (author), Xia, Jianye (author), Reuss, Matthias (author), Heijnen, J.J. (author), Noorman, H.J. (author), Mudde, R.F. (author)
The trajectories, referred to as lifelines, of individual microorganisms in an industrial scale fermentor under substrate limiting conditions were studied using an Euler-Lagrange computational fluid dynamics approach. The metabolic response to substrate concentration variations along these lifelines provides deep insight in the dynamic...
journal article 2016
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