document

A multilevel optimization approach to route design and flight allocation taking aircraft sequence and separation constraints into account

Ho-Huu, V. (author), Hartjes, S. (author), Perez Castan, J.A. (author), Visser, H.G. (author), Curran, R. (author)

This paper presents the development of a multilevel optimization framework for the design and selection of departure routes, and the distribution of aircraft movements among these routes, while taking the sequence and separation requirements for aircraft on runways and along selected routes into account. The main aim of the framework is to...

journal article 2020

document

Uptake and subcellular distribution of radiolabeled polymersomes for radiotherapy

Roobol, Stefan J. (author), Hartjes, Thomas A. (author), Slotman, Johan A. (author), de Kruijff, R.M. (author), Kanaar, R. (author), Houtsmuller, A.B. (author), Denkova, A.G. (author), van Royen, M.E. (author), Essers, J. (author)

Polymersomes have the potential to be applied in targeted alpha radionuclide therapy, while in addition preventing release of recoiling daughter isotopes. In this study, we investigated the cellular uptake, post uptake processing and intracellular localization of polymersomes. Methods: High-content microscopy was used to validate polymersome...

journal article 2020

document

An optimization framework for route design and allocation of aircraft to multiple departure routes

Ho-Huu, V. (author), Hartjes, S. (author), Visser, H.G. (author), Curran, R. (author)

In this article, we present the development of a two-step optimization framework to deal with the design and selection of aircraft departure routes and the allocation of flights among these routes. The aim of the framework is to minimize cumulative noise annoyance and fuel burn. In the first step of the framework, multi-objective trajectory...

journal article 2019

document

Trajectory optimization of extended formation flights for commercial aviation

Hartjes, S. (author), Visser, H.G. (author), Hubar, Marco E.G.van Hellenberg (author)

This paper presents a trajectory optimization study that has been conducted using a recently developed tool for the synthesis and analysis of extended flight formations of long-haul commercial aircraft, with the aim to minimize overall fuel consumption. In extended flight formations, trailing aircraft can attain an appreciable reduction in...

journal article 2019

document

Extracellular vesicle quantification and characterization: Common methods and emerging approaches

Hartjes, Thomas A. (author), Mytnyk, S. (author), Jenster, G. (author), van Steijn, V. (author), van Royen, M.E. (author)

Extracellular vesicles (EVs) are a family of small membrane vesicles that carry information about cells by which they are secreted. Growing interest in the role of EVs in intercellular communication, but also in using their diagnostic, prognostic and therapeutic potential in (bio) medical applications, demands for accurate assessment of their...

review 2019

document

Simultaneous design of different aircraft departure routes taking community noise exposure events into account

Ho-Huu, V. (author), Hartjes, S. (author), Visser, H.G. (author), Curran, R. (author)

At many airports, ground track segments may be shared by different departure routes, and the population living underneath these segments is exposed to all aircraft movements which are sent to these routes. This may cause negative community reaction to authorities and policymakers, leading to objections against the expansion of airport and...

conference paper 2019

document

Air traffic assignment based on daily population mobility to reduce aircraft noise effects and fuel consumption

Ho-Huu, V. (author), Ganić, Emir (author), Hartjes, S. (author), Babić, Obrad (author), Curran, R. (author)

The paper first investigates the influence of daily mobility of population on evaluation of aircraft noise effects. Then, a new air traffic assignment model that considers this activity is proposed. The main objective is to reduce the number of people affected by noise via lowering as much as possible the noise exposure level L <sub>den</sub...

journal article 2019

document

Integrated design and allocation of optimal aircraft departure routes

Ho-Huu, V. (author), Hartjes, S. (author), Visser, H.G. (author), Curran, R. (author)

This paper presents a new multi-objective optimization formulation for the design and allocation of optimal aircraft departure routes. In the considered problem – besides two conventional objectives based on cumulative noise criteria and fuel burn – a new objective considering the flight frequency is introduced. Moreover, to take advantage of...

journal article 2018

document

An improved MOEA/D algorithm for bi-objective optimization problems with complex Pareto fronts and its application to structural optimization

Ho-Huu, V. (author), Hartjes, S. (author), Visser, H.G. (author), Curran, R. (author)

The multi-objective evolutionary algorithm based on decomposition (MOEA/D) has been recognized as a promising method for solving multi-objective optimization problems (MOPs), receiving a lot of attention from researchers in recent years. However, its performance in handling MOPs with complicated Pareto fronts (PFs) is still limited,...

journal article 2018

document

Multiple-phase trajectory optimization for formation flight in civil aviation

Hartjes, S. (author), van Hellenberg Hubar, Marco (author), Visser, H.G. (author)

In this paper a tool is developed that optimizes the trajectories of multiple airliners that seek to join in formation to minimize overall fuel consumption or direct operating cost. The developed optimization framework relies on optimal control theory to solve the multiple-phase optimization problem associated to flight formation assembly. A...

journal article 2018

document

Noise analysis of aircraft departure procedures using MONTE CARLO simulation

Smits, Tommy (author), Hartjes, S. (author), Mitici, M.A. (author)

During arrival and departure procedures at an airport, aircraft generate noise. High levels of noise during these terminal procedures can have a negative impact on the communities located near the airport. We assess the impact of the noise generated by a standard instrument departure of a twin-engine narrow body mid-range aircraft over the...

conference paper 2018

document

Air traffic assignment to reduce population noise exposure and fuel consumption using multi-criteria optimisation

Ganić, Emir (author), Ho-Huu, V. (author), Babić, Obrad (author), Hartjes, S. (author)

Air traffic assignment to departure and arrival routes has a major impact on the population noise exposure in the vicinity of the airport. In some cases, by choosing the suitable air traffic assignment it is possible to avoid overflying populated areas and reduce number of people affected by noise. However, such an approach almost always leads...

conference paper 2018

document

Optimization of noise abatement aircraft terminal routes using a multi-objective evolutionary algorithm based on decomposition

Ho-Huu, V. (author), Hartjes, S. (author), Geijselaers, L.H. (author), Visser, H.G. (author), Curran, R. (author)

Recently, a multi-objective evolutionary algorithm based on decomposition (MOEA/D) has emerged as a potential method for solving multi-objective optimization problems (MOPs) and attracted much attention from researchers. In MOEA/D, the MOPs are decomposed into a number of scalar optimization sub-problems, and these sub-problems are optimized...

conference paper 2018

document

Optimal Control Approach to Helicopter Noise Abatement Trajectories in Nonstandard Atmospheric Conditions

Hartjes, S. (author), Visser, H.G. (author)

This paper discusses the development of a software suite that aims to optimize helicopter trajectories with respect to the noise impact on the ground. The software suite has been developed around an advanced gradient-based optimization algorithm based on optimal control theory. The helicopter trajectories are modeled using an eight-degree-of...

journal article 2018

document

Helicopter noise footprint prediction in unsteady maneuvers

Gennaretti, Massimo (author), Bernardini, Giovanni (author), Serafini, Jacopo (author), Anobile, A. (author), Hartjes, S. (author)

This paper investigates different methodologies for the evaluation of the acoustic disturbance emitted by helicopter’s main rotors during unsteady maneuvers. Nowadays, the simulation of noise emitted by helicopters is of great interest to designers, both for the assessment of the acoustic impact of helicopter flight on communities and for the...

journal article 2017

document

An Efficient Application of the MOEA/D Algorithm for Designing Noise Abatement Departure Trajectories

Ho-Huu, V. (author), Hartjes, S. (author), Visser, H.G. (author), Curran, R. (author)

In an effort to allow to increase the number of aircraft and airport operations while mitigating their negative impacts (e.g., noise and pollutant emission) on near-airport communities, the optimal design of new departure routes with less noise and fuel consumption becomes more important. In this paper, a multi-objective evolutionary algorithm...

journal article 2017

document

Efficient trajectory parameterization for environmental optimization of departure flight paths using a genetic algorithm

Hartjes, S. (author), Visser, H.G. (author)

In this study, a genetic optimization algorithm is applied to the design of environmentally friendly aircraft departure trajectories. The environmental optimization has been primarily focused on noise abatement and local NOx emissions, whilst taking fuel burn into account as an economical criterion. In support of this study, a novel...

journal article 2016

document

Experimental/numerical acoustic correlation of helicopter unsteady MANOEUVRES

Gennaretti, Massimo (author), Bernardini, Giovanni (author), Hartjes, S. (author), Scandroglio, Alessandro (author), Riviello, Luca (author), Paolone, Enrico (author)

This paper presents one of the main objective of WP1 of Clean Sky GRC5 MANOEUVRES project, which consists in the correlation of ground noise data measured during flight tests, with numerical predictions obtained by a numerical process aimed at the analysis of the acoustic field emitted by helicopter rotors in arbitrary unsteady manoeuvring...

conference paper 2016

document

An Optimal Control Approach to Helicopter Noise and Emissions Abatement Terminal Procedures

Hartjes, S. (author)

Civil aviation plays an irreplaceable role in the current global civilization. Even though the 2008 economic crisis has limited growth in the western world, it can only be expected that due to continuing development in the Far East, South America and Africa this role will increase further over the years to come. Also in the field of helicopter...

doctoral thesis 2015

document

Methodologies for helicopter noise footprint prediction in maneuvering flights

Bernardini, Giovanni (author), Anobile, Alessandro (author), Serafini, Jacopo (author), Hartjes, S. (author), Gennaretti, Massimo (author)

This paper investigates different techniques for the evaluation of the acoustic disturbance emitted by helicopters in unsteady maneuvers. Nowadays, the simulation of noise emitted by helicopters is of great interest to designers, both for assessing the acoustic impact of helicopter flight on communities and for identifying optimal-noise...

conference paper 2015