Synergistic effects of cerium-containing bioactive glasses and apoptotic extracellular vesicles alleviate bisphosphonate-related osteonecrosis of jaw

Bisphosphonates (BPs) are commonly used to treat skeletal diseases. However, long-term use of BPs can lead to BP-related jaw bone necrosis (BRONJ), particularly in patients undergoing tooth extraction surgery. The treatment of BRONJ remains challenging due to the local inflammatory microenvironment. To address this issue, we developed...

Multi-view Contour-constrained Transformer Network for Thin-cap Fibroatheroma Identification

Identification and detection of thin-cap fibroatheroma (TCFA) from intravascular optical coherence tomography (IVOCT) images is critical for treatment of coronary heart diseases. Recently, deep learning methods have shown promising successes in TCFA identification. However, most methods usually do not effectively utilize multi-view...

A novel 4H-SiC multiple stepped SGT MOSFET with improved high frequency figure of merit

A novel 4H-SiC Multiple Stepped SGT MOSFET (MSGT-MOSFET) is presented and investigated utilizing TCAD simulations in this paper. We have quantitatively studied the characteristics of the device through simulation modeling and physical model calculations, and comparatively analyzed the performance and application prospects of this novel device...

Investigation of Unclamped Inductive Switch Characteristics in 4H-SiC MOSFETs With Different Cell Topologies

To investigate the unclamped inductive switch (UIS) characteristics, 1200 V silicon carbide (SiC) planar MOSFETs with four cell topologies of linear, current sharing linear, square, and hexagon are designed and manufactured. The experimental platform was built and tested. The results show that the single pulse avalanche energy density of the...

Predicting adsorption isotherms of organic micropollutants by high-silica zeolite mixtures

One framework type of high-silica zeolite only can effectively remove a limited range of organic micropollutants (OMPs) from water. In order to extend the OMP removal range, different types of high-silica zeolites need to be combined in the adsorption process. In this study, Mordernite (MOR) and ZSM-5 (MFI) high-silica zeolite powders were mixed...

First demonstration of l-band high-power limiter with gan schottky barrier diodes (Sbds) based on steep-mesa technology

Gallium nitride (GaN) has attracted increased attention because of superior material properties, such as high electron saturation velocity and high electrical field strength, which are promising for high-power microwave applications. We report on a high-performance vertical GaN-based Schottky barrier diode (SBD) and its demonstration in a...

Low Leakage and High Forward Current Density Quasi-Vertical GaN Schottky Barrier Diode With Post-Mesa Nitridation

In this brief, a high-performance quasi-vertical GaN Schottky barrier diode (SBD) on sapphire substrate with post-mesa nitridation process is reported, featuring a low damaged sidewall with extremely low leakage current. The fabricated SBD with a drift layer of 1 μm has achieved a very high ON/OFF current ratio (Iscriptscriptstyle ON...

High-power and broadband microwave detection with a quasi-vertical GaN Schottky barrier diode by novel post-mesa nitridation

We report a high-performance GaN Schottky barrier diode (SBD) on a sapphire substrate with a novel post-mesa nitridation technique and its application in a high-power microwave detection circuit. The fabricated SBD achieved a very high forward current density of 9.19 kA cm-2 at 3 V, a low specific on-resistance (RON,sp) of 0.22 mO cm2 and...

Corrected method for scaling the dynamic response of stiffened plate subjected to blast load

Test on a small scaled model is an effective approach to predict the dynamic response of full scale structure under blast loadings. However, the geometric dimensions of specimens cannot simply comply with complete geometrical similarity due to manufacture or test restrictions. It would result in the difference structural performance between...

An adaptive end-to-end classification approach for mobile laser scanning point clouds based on knowledge in urban scenes

It is fundamental for 3D city maps to efficiently classify objects of point clouds in urban scenes. However, it is still a large challenge to obtain massive training samples for point clouds and to sustain the huge training burden. To overcome it, a knowledge-based approach is proposed. The knowledge-based approach can explore discriminating...

Cooperative distributed predictive control for collision-free vehicle platoons

The rapidly developing computing and communication technologies improve the autonomy of individual vehicles on the one hand and facilitate the coordination among vehicles on the other. In the context of dynamic speed management, this study considers a platoon of intelligent vehicles that are required to maintain desired inter-vehicle spaces and...

Direct imaging of the circular chromosome in a live bacterium

Although the physical properties of chromosomes, including their morphology, mechanics, and dynamics are crucial for their biological function, many basic questions remain unresolved. Here we directly image the circular chromosome in live E. coli with a broadened cell shape. We find that it exhibits a torus topology with, on average, a lower...

Cell Boundary Confinement Sets the Size and Position of the E. coli Chromosome

Although the spatiotemporal structure of the genome is crucial to its biological function, many basic questions remain unanswered on the morphology and segregation of chromosomes. Here, we experimentally show in Escherichia coli that spatial confinement plays a dominant role in determining both the chromosome size and position. In non...

Study on the Mg-Li-Zn ternary alloy system with improved mechanical properties, good degradation performance and different responses to cells

Novel Mg-(3.5, 6.5wt%)Li-(0.5, 2, 4wt%)Zn ternary alloys were developed as new kinds of biodegradable metallic materials with potential for stent application. Their mechanical properties, degradation behavior, cytocompatibility and hemocompatibility were studied. These potential biomaterials showed higher ultimate tensile strength than...

Airborne LiDAR data filtering based on geodesic transformations of mathematical morphology

The capability of acquiring accurate and dense three-dimensional geospatial information that covers large survey areas rapidly enables airborne light detection and ranging (LiDAR) has become a powerful technology in numerous fields of geospatial applications and analysis. LiDAR data filtering is the first and essential step for digital elevation...