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Odijk, T. (author)
A scaling analysis is presented of the statistics of long DNA confined in nanochannels and nanoslits. It is argued that there are several regimes in between the de Gennes and Odijk limits introduced long ago. The DNA chain folds back on itself giving rise to a global persistence length that may be very large owing to entropic deflection....
journal article 2008
document
Prinsen, P. (author), Odijk, T. (author)
A theory is set up of spherical proteins interacting by screened electrostatics and constant adhesion, in which the effective adhesion parameter is optimized by a variational principle for the free energy. An analytical approach to the second virial coefficient is first outlined by balancing the repulsive electrostatics against part of the bare...
journal article 2004
document
Yuan, C.A. (author), Zhang, G.Q. (author), Han, C.N. (author), Chiang, K.N. (author), Cui, Y. (author)
The mechanical characteristics of the long-chain double-stranded DNA (dsDNA) molecule under the axial stretching and lateral unzipping are studied by the clustered atomistic-continuum method (CACM). The CACM consisted of the clustered atom method (CAM) and the atomistic-continuum method (ACM). The CAM treats the specific atomic group as the...
journal article 2007
document
Odijk, T. (author)
A theory is presented of the elongation of double-stranded DNA confined in a nanochannel based on a study of the formation of hairpins. A hairpin becomes constrained as it approaches the wall of a channel which leads to an entropic force causing the hairpin to tighten. The DNA in the hairpin remains double-stranded. The free energy of the...
journal article 2006
document
Geschiere, S.D. (author), Ziemecka, I. (author), Van Steijn, V. (author), Koper, G.J.M. (author), Van Esch, J.H. (author), Kreutzer, M.T. (author)
This paper studies the Rayleigh-Plateau instability for co-flowing immiscible aqueous polymer solutions in a microfluidic channel. Careful vibration-free experiments with controlled actuation of the flow allowed direct measurement of the growth rate of this instability. Experiments for the well-known aqueous two phase system (ATPS, or aqueous...
journal article 2012
document
Lipfert, J. (author), Kerssemakers, J.J.W. (author), Rojer, M. (author), Dekker, N.H. (author)
The double helical nature of DNA links many cellular processes such as DNA replication, transcription, and repair to rotational motion and the accumulation of torsional strain. Magnetic tweezers (MTs) are a single-molecule technique that enables the application of precisely calibrated stretching forces to nucleic acid tethers and to control...
journal article 2011
document
Brinkers, S. (author), Dietrich, H.R.C. (author), De Groote, F.H. (author), Young, I.T. (author), Rieger, B. (author)
The wormlike chain model describes the micromechanics of semiflexible polymers by introducing the persistence length. We propose a method of measuring the persistence length of DNA in a controllable near-native environment. Using a dark field microscope, the projected positions of a gold nanoparticle undergoing constrained Brownian motion are...
journal article 2009
document
Huis In 't Veld, Pim J. (author), Volkov, V. (author), Stender, Isabelle D. (author), Musacchio, Andrea (author), Dogterom, A.M. (author)
Errorless chromosome segregation requires load-bearing attachments of the plus ends of spindle microtubules to chromosome structures named kinetochores. How these end-on kinetochore attachments are established following initial lateral contacts with the microtubule lattice is poorly understood. Two microtubule-binding complexes, the Ndc80 and...
journal article 2019
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