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Klein, S. (author), Vast, E. (author), Van Soest, J. (author), Dekker, A. (author), Koek, M. (author), Niessen, W.J. (author)
1st Clinical Research Informatics (CRI) Solutions Day Duesseldorf, Germany, 26-27 May 2014
journal article 2015
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Tans, S.J. (author), Geerligs, L.J. (author), Dekker, C. (author), Wu, J. (author), Wegner, G. (author)
journal article 1997
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Dulin, D. (author), Arnold, Jamie J. (author), van Laar, T. (author), Oh, Hyung Suk (author), Lee, Cheri (author), Perkins, Angela L. (author), Harki, Daniel A. (author), Depken, S.M. (author), Cameron, Craig E. (author), Dekker, N.H. (author)
RNA viruses pose a threat to public health that is exacerbated by the dearth of antiviral therapeutics. The RNA-dependent RNA polymerase (RdRp) holds promise as a broad-spectrum, therapeutic target because of the conserved nature of the nucleotide-substrate-binding and catalytic sites. Conventional, quantitative, kinetic analysis of antiviral...
journal article 2017
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Moolman, M.C. (author), Tiruvadi Krishnan, S. (author), Kerssemakers, J.W.J. (author), Van den Berg, A. (author), Tulinski, P. (author), Depken, M. (author), Reyes-Lamothe, R. (author), Sherratt, D.J. (author), Dekker, N.H. (author)
The ubiquitous sliding clamp facilitates processivity of the replicative polymerase and acts as a platform to recruit proteins involved in replication, recombination and repair. While the dynamics of the E. coli ?2-sliding clamp have been characterized in vitro, its in vivo stoichiometry and dynamics remain unclear. To probe both ?2-clamp...
journal article 2014
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Mantel, O.C. (author), Bal, C.A.W. (author), Langezaal, C. (author), Dekker, C. (author), Van der Zant, H.S.J. (author)
journal article 1999
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Caneva, S.L. (author), Gehring, P. (author), García-Suárez, Víctor M. (author), García-Fuente, Amador (author), Stefani, D. (author), Olavarria Contreras, I.J. (author), Ferrer, Jaime (author), Dekker, C. (author), van der Zant, H.S.J. (author)
The ability to detect and distinguish quantum interference signatures is important for both fundamental research and for the realization of devices such as electron resonators<sup>1</sup>, interferometers<sup>2</sup> and interference-based spin filters<sup>3</sup>. Consistent with the principles of subwavelength optics, the wave nature of...
journal article 2018
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van Oene, M.M. (author), Dickinson, L.E. (author), Cross, B. (author), Pedaci, F. (author), Lipfert, J. (author), Dekker, N.H. (author)
The bacterial flagellar motor of Escherichia coli is a nanoscale rotary engine essential for bacterial propulsion. Studies on the power output of single motors rely on the measurement of motor torque and rotation under external load. Here, we investigate the use of magnetic tweezers, which in principle allow the application and active control...
journal article 2017
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Ketterer, Philip (author), Ananth, A.N. (author), Laman Trip, J.D.S. (author), Mishra, Ankur (author), Bertosin, Eva (author), Ganji, M. (author), van der Torre, J. (author), Onck, Patrick (author), Dietz, Hendrik (author), Dekker, C. (author)
The nuclear pore complex (NPC) is the gatekeeper for nuclear transport in eukaryotic cells. A key component of the NPC is the central shaft lined with intrinsically disordered proteins (IDPs) known as FG-Nups, which control the selective molecular traffic. Here, we present an approach to realize artificial NPC mimics that allows controlling...
journal article 2018
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Vlijm, R. (author), Lee, M. (author), Ordu, O. (author), Boltengagen, A. (author), Lusser, A. (author), Dekker, N.H. (author), Dekker, C. (author)
Eukaryotic nucleosomes consists of an (H3-H4)2 tetramer and two H2A-H2B dimers, around which 147 bp of DNA are wrapped in 1.7 left-handed helical turns. During chromatin assembly, the (H3-H4)2 tetramer binds first, forming a tetrasome that likely constitutes an important intermediate during ongoing transcription. We recently showed that (H3-H4)2...
journal article 2015
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Savov, A.M. (author), Joshi, S. (author), Shafqat, Salman (author), Hoefnagels, Johan (author), Louwerse, M.C. (author), Stoute, R. (author), Dekker, R. (author)
A device for studying the mechanical and electrical behavior of free-standing micro-fabricated metal structures, subjected to a very large deformation, is presented in this paper. The free-standing structures are intended to serve as interconnects in high-density, highly stretchable electronic circuits. For an easy, damage-free handling and...
journal article 2018
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Kong, J. (author), LeRoy, B.J. (author), Lemay, S.G. (author), Dekker, C. (author)
We have developed a fabrication process for incorporating a gate electrode into suspended single-walled carbon nanotube structures for scanning tunneling spectroscopy studies. The nanotubes are synthesized by chemical vapor deposition directly on a metal surface. The high temperature (800?°C) involved in the growth process poses challenging...
journal article 2005
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Genani, G. (author), Dekker, M.C. (author), Molenbroek, J.F.M. (author)
An investigation of existing literature reveals that guitar players are most prone to musculoskeletal injuries amongst all musicians. In the light of recent injuries to prominent guitar players such as Eddie Van Halen, this article explores ergonomics of electric guitars. By means of surveys, user observations, biomechanical analysis and...
journal article 2013
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Eeftens, J.M. (author), Bisht, Shveta (author), Kerssemakers, J.W.J. (author), Kschonsak, Marc (author), Haering, Christian H. (author), Dekker, C. (author)
Condensin, a conserved member of the SMC protein family of ring-shaped multi-subunit protein complexes, is essential for structuring and compacting chromosomes. Despite its key role, its molecular mechanism has remained largely unknown. Here, we employ single-molecule magnetic tweezers to measure, in real time, the compaction of individual...
journal article 2017
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Kleinknecht, A. (author), Dekker, R. (author), Zhou, H. (author)
Firms with high shares of workers on fixed-term contracts have significantly higher sales of imitative new products but perform significantly worse on sales of innovative new products (“first on the market”). High functional flexibility in “insider-outsider” labor markets enhances a firm’s new product sales, as do training efforts and highly...
journal article 2009
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Burnham, D.R. (author), De Vlaminck, I. (author), Henighan, T. (author), Dekker, C. (author)
Measurements in magnetic tweezers rely upon precise determination of the position of a magnetic microsphere. Fluctuations in the position due to Brownian motion allows calculation of the applied force, enabling deduction of the force-extension response function for a single DNA molecule that is attached to the microsphere. The standard approach...
journal article 2014
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LeRoy, B.J. (author), Kong, J. (author), Pahilwani, V.K. (author), Dekker, C. (author), Lemay, S.G. (author)
journal article 2005
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Moene, R. (author), Dekker, J.P. (author), Makkee, M. (author), Schoonman, J. (author), Moulijn, J.A. (author)
journal article 1994
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Dekker, R. (author)
“A what on a chip?” is what most people ask with disbelief when they hear for the first time of the new and very exciting research area “Organ on a Chip.” The topic has nothing to do with Science Fiction, but everything with a very surprising encounter between two completely different research fields: Microfabrication and Stem-Cell Biology! The...
journal article 2013
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Smeets, R.M.M. (author), Keyser, U.F. (author), Wu, M.Y. (author), Dekker, N.H. (author), Dekker, C. (author)
journal article 2006
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Van der Zant, H.S.J. (author), Mantel, O.C. (author), Dekker, C. (author), Mooij, J.E. (author), Traeholt, C. (author)
journal article 1996
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