Establishing In Vitro Organoid-Based Epithelial-Mesenchymal Transition Model in Cholangiocarcinoma Including Tumor Extracellular Environment

Cholangiocarcinoma (CCA) is a highly aggressive biliary tumor with a poor prognosis and limited treatment options. Various critical aspects of CCA development remain unclear. Lately, the dynamic process of epithelial-mesenchymal transition (EMT) was highlighted to play a crucial role in the fundamental mechanism of metastatic dissemination....