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Ercan, O. (author), Bisschops, M.M. (author), Overkamp, W. (author), Jørgensen, T.R. (author), Rama, A.F. (author), Smid, E.J. (author), Pronk, J.T. (author), Kuipers, O.P. (author), Daran-Lapujade, P. (author), Kleerebezem, M. (author)
The current knowledge of the physiology and gene expression of industrially relevant microorganisms is largely based on laboratory studies under conditions of rapid growth and high metabolic activity. However, in natural ecosystems and industrial processes, microbes frequently encounter severe calorie restriction. As a consequence, microbial...
journal article 2015
document
Ercan, O. (author), Wels, M. (author), Smid, E.J. (author), Kleerebezem, M. (author)
This paper describes the transcriptional adaptations of nongrowing, retentostat cultures of Lactococcus lactis to starvation. Near-zero-growth cultures (? = 0.0001 h?1) obtained by extended retentostat cultivation were exposed to starvation by termination of the medium supply for 24 h, followed by a recovery period of another 24 h by...
journal article 2015
document
Ercan, O. (author), Wels, M. (author), Smid, E.J. (author), Kleerebezem, M. (author)
This paper describes the molecular and metabolic adaptations of Lactococcus lactis during the transition from a growing to a near-zero growth state by using carbon-limited retentostat cultivation. Transcriptomic analyses revealed that metabolic patterns shifted between lactic- and mixed-acid fermentations during retentostat cultivation, which...
journal article 2015