Putting on molecular weight: Enabling cryo-EM structure determination of sub-100-kDa proteins

Significant advances in the past decade have enabled high-resolution structure determination of a vast variety of proteins by cryogenic electron microscopy single particle analysis. Despite improved sample preparation, next-generation imaging hardware, and advanced single particle analysis algorithms, small proteins remain elusive for...

Towards evolutionary predictions: Current promises and challenges

Evolution has traditionally been a historical and descriptive science, and predicting future evolutionary processes has long been considered impossible. However, evolutionary predictions are increasingly being developed and used in medicine, agriculture, biotechnology and conservation biology. Evolutionary predictions may be used for...

Preparation, properties, and applications of magnetic hematite microparticles

Hematite microparticles are becoming increasingly important components in the soft matter field. The remarkable combination of magnetic and photocatalytic properties that characterize them, coupled with the variety of uniform and monodisperse shapes that they can be synthesized in, makes them a one of a kind colloidal model system. Thanks to...

Causes of Quality Failures in Building Energy Renovation Projects of Northern China: A Review and Empirical Study

Building energy renovations can effectively improve the environmental performance and energy sustainability of existing buildings. From 2007 onwards, the Chinese government has promoted energy-saving renovations of existing urban residential buildings. Nevertheless, various quality failures happen during the construction period in energy-saving...

Latrophilin’s social protein network

Latrophilins (LPHNs) are adhesion GPCRs that are originally discovered as spider’s toxin receptors, but are now known to be involved in brain development and linked to several neuronal and non-neuronal disorders. Latrophilins act in conjunction with other cell adhesion molecules and may play a leading role in its network organization. Here,...