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de Kruijff, R.M. (author), Raavé, René (author), Kip, Annemarie M. (author), Molkenboer-Kuenen, Janneke (author), Morgenstern, Alfred (author), Bruchertseifer, Frank (author), Heskamp, Sandra (author), Denkova, A.G. (author)
Increasing attention is given to personalized tumour therapy, where α-emitters can potentially play an important role. Alpha particles are ideal for localized cell killing because of their high linear energy transfer and short ranges. However, upon the emission of an α particle the daughter nuclide experiences a recoil energy large enough to...
journal article 2019
document
Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)
Background In this work, a lutetium-177 (177Lu) production method based on the separation of nuclear isomers, 177mLu & 177Lu, is reported. The 177mLu-177Lu separation is performed by combining the use of DOTA & DOTA-labelled peptide (DOTATATE) and liquid-liquid extraction. Methods The 177mLu cations were complexed with DOTA &...
journal article 2019
document
Warman, J.M. (author), de Haas, M.P. (author), Luthjens, L.H. (author), Denkova, A.G. (author), Yao, T. (author)
We review the development and application of an organic polymer-gel capable of producing fixed, three-dimensional fluorescent images of complex radiation fields. The gel consists for more than 99% of γ-ray-polymerized (~15% conversion) tertiary-butyl acrylate (TBA) containing ~100 ppm of a fluorogenic compound, e.g., maleimido-pyrene (MPy). The...
journal article 2018
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Bhardwaj, R. (author), van der Meer, A.J.G.M. (author), Das, S.K. (author), de Bruin, M (author), Gascon, Jorge (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)
177Lu has sprung as a promising radionuclide for targeted therapy. The low soft tissue penetration of its β− emission results in very efficient energy deposition in small-size tumours. Because of this, 177Lu is used in the treatment of neuroendocrine tumours and is also clinically approved for prostate cancer therapy. In this work, we report a...
journal article 2017
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Laan, A.C. (author), Denkova, A.G. (author)
This letter is meant to make scientists aware of the proper application of transmission electron microscopy (TEM) for the assessment of polymeric self-assemblies. Cryogenic (cryo)-TEM should be the method of choice. Here, we show the difference in morphologies observed in the same sample when using cryo-TEM and when using TEM with drying,...
journal article 2017
document
Laan, A.C. (author), Santini, C. (author), Jennings, L. (author), De Jong, M. (author), Bernsen, M.R. (author), Denkova, A.G. (author)
Background Single photon emission computed tomography (SPECT) is an indispensable tool in the determination of the in vivo fate of polymeric micelles. However, for this purpose, the micelles need to be radiolabeled, and almost all radiolabeling procedures published to date involve the conjugation of a chelating agent to the constituting polymer,...
journal article 2016
document
De Kruijff, R.M. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author)
This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides...
journal article 2015
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