Computational Biology in Clinical Proteomics and Chromatin Genomics

The work in this thesis is concerned with two very distinct biological fields. The first part pertains to the development of techniques to aid in the search for clinical biomarkers for use in the early detection of cancer. The second part aims to elucidate in what way a genome is organised in a cell nucleus and the functional consequences of...

Data-driven modelling of protein synthesis: A sequence perspective

Recent advances in DNA sequencing, synthesis and genetic engineering have enabled the introduction of choice DNA sequences into living cells. This is an exciting prospect for the field of industrial biotechnology, which aims at using microorganisms to produce foods, beverages, pharmaceuticals and fine- and bulk chemicals in a sustainable fashion...

Divided Cities: Increasing Socio-Spatial Polarization within Large Cities in the Netherlands (discussion paper)

There is increasing evidence that our societies are polarizing. Most studies focus on labour market and educational outcomes and show a socioeconomic polarization of the bottom and top ends of the population distribution. Processes of social polarization have a spatial dimension which should be visible in the changing mosaic of neighbourhoods in...

Contextualised mobility histories of moving desires and actual moving behaviour (discussion paper)

Conceptually, adopting a life course approach when analysing residential mobility enables us to investigate how experiencing particular life events affects mobility decision-making and behaviour throughout individual lifetimes. Yet although a growing body of longitudinal research links mobility decision-making to subsequent moving behaviour,...

Intergenerational transmission of neighbourhood poverty: An analysis of neighbourhood histories of individuals

Marie Curie programme under the European Union's Seventh Framework Programme (FP/2007-2013) / Career Integration Grant n. PCIG10-GA-2011-303728 (CIG Grant NBHCHOICE, Neighbourhood choice, neighbourhood sorting, and neighbourhood effects). The extent to which socioeconomic (dis)advantage is transmitted between generations is receiving increasing...

Intergenerational Transmission of Neighbourhood Poverty in Sweden: An Innovative Analysis of Individual Neighbourhood Histories (discussion paper)

The extent to which socioeconomic (dis)advantage is transmitted between generations is receiving increasing attention from academics and policymakers. However, few studies have investigated whether there is a spatial dimension to this intergenerational transmission of (dis)advantage. Drawing upon the concept of a neighbourhood biography, this...

The Moderating Effect of Higher Education on Intergenerational Spatial Inequality (discussion paper)

It is well-known that socioeconomic outcomes and (dis)advantage over the life course can be transmitted from parent to child. It is increasingly suggested that these intergenerational effects also have a spatial dimension, although empirical research into this topic remains scarce. Previous research from Sweden and the United States shows that...

Ethnic differences in family trajectories of young adult women in the Netherlands: Timing and sequencing of events

Background: Despite extensive research on the family behavior of young adults, family dynamics of children of migrants remain largely unexplored. This is unfortunate as family transitions are strongly interlinked with transitions in other domains (e.g., education, work) and predictive for outcomes later in life.<br/><br/>Objective: We provide a...

The moderating effect of higher education on the intergenerational transmission of residing in poverty neighbourhoods

It is well-known that socioeconomic outcomes and (dis)advantage over the life course can be transmitted from parent to child. It is increasingly suggested that these intergenerational effects also have a spatial dimension, although empirical research into this topic remains scarce. Previous research from Sweden and the United States shows that...

Intergenerational transmission of neighbourhood poverty in Sweden: An innovative analysis of individual neighbourhood histories

The extent to which socioeconomic (dis)advantage is transmitted between generations is receiving increasing attention from academics and policymakers. However, few studies have investigated whether there is a spatial dimension to this intergenerational transmission of (dis)advantage. Drawing upon the concept of a neighbourhood biography, this...

The Temporal Dynamics of Neighborhood Disadvantage in Childhood and Subsequent Problem Behavior in Adolescence

Research on neighborhood effects has increasingly focused on how long children have lived in a deprived neighborhood during childhood (duration), but has typically ignored when in childhood the exposure occurred (timing) and whether circumstances were improving or deteriorating (sequencing). Using Dutch register data, we applied sequence...

Ethnic Differences in Duration and Timing of Exposure to Neighbourhood Disadvantage during Childhood

This paper examines ethnic differences in childhood neighborhood disadvantage among children living in the Netherlands. In contrast to more conventional approaches for assessing children’s exposure to neighborhood poverty and affluence (e.g., point-in-time and cumulative measures of exposure), we apply sequence analysis to simultaneously capture...