"uuid","repository link","title","author","contributor","publication year","abstract","subject topic","language","publication type","publisher","isbn","issn","patent","patent status","bibliographic note","access restriction","embargo date","faculty","department","research group","programme","project","coordinates" "uuid:47632dfc-4c6a-4860-8a7b-d803d5bc6395","http://resolver.tudelft.nl/uuid:47632dfc-4c6a-4860-8a7b-d803d5bc6395","Combined optical sizing and acoustical characterization of single freely-floating microbubbles","Luan, Ying (Erasmus MC); Renaud, Guillaume (Erasmus MC; UPMC-Sorbonne Universités & CNRS); Raymond, Jason L. (Erasmus MC); Segers, Tim (University of Twente); Lajoinie, Guillaume (University of Twente); Beurskens, Robert (Erasmus MC); Mastik, Frits (Erasmus MC); Kokhuis, Tom J A (Erasmus MC); van der Steen, A.F.W. (TU Delft ImPhys/Acoustical Wavefield Imaging; Erasmus MC); Versluis, Michel (University of Twente); de Jong, N. (TU Delft ImPhys/Acoustical Wavefield Imaging; Erasmus MC)","","2016","In this study we present a combined optical sizing and acoustical characterization technique for the study of the dynamics of single freely-floating ultrasound contrast agent microbubbles exposed to long burst ultrasound excitations up to the milliseconds range. A co-axial flow device was used to position individual microbubbles on a streamline within the confocal region of three ultrasound transducers and a high-resolution microscope objective. Bright-field images of microbubbles passing through the confocal region were captured using a high-speed camera synchronized to the acoustical data acquisition to assess the microbubble response to a 1-MHz ultrasound burst. Nonlinear bubble vibrations were identified at a driving pressure as low as 50 kPa. The results demonstrate good agreement with numerical simulations based on the shell-buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499-3505 (2005)]. The system demonstrates the potential for a high-throughput in vitro characterization of individual microbubbles.","Ultranonography; Bubble dynamics; Nonlinear dynamics; Vibration testing; Cameras","en","journal article","","","","","","","","2017-12-07","","","ImPhys/Acoustical Wavefield Imaging","","",""