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Douma, F.A. (author), Witteveen, M. (author), Verheij, H.J. (author)
report 1994
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Douma, F.A. (author)
report 1994
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Douma, F.A. (author), Menke, M.A. (author), Ruygh, E.F.W. (author)
report 1994
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Douma, F.A. (author), Verheij, H.J. (author), Witteveen, M. (author)
report 1995
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Boom, B. (author), Douma, E. (author), Van Eekelen, A. (author), Schoenmakers, P. (author)
report 2001
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Douma, S.G. (author)
doctoral thesis 2006
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Gidijala, L. (author), Kiel, J.A.K.W. (author), Douma, R.D. (author), Seifar, R.M. (author), Van Gulik, W.M. (author), Bovenberg, R.A.L. (author), Veenhuis, M. (author), Van Klei, I.J. (author)
This study aimed at developing an alternative host for the production of penicillin (PEN). As yet, the industrial production of this β-lactam antibiotic is confined to the filamentous fungus Penicillium chrysogenum. As such, the yeast Hansenula polymorpha, a recognized producer of pharmaceuticals, represents an attractive alternative....
journal article 2009
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Douma, R.D. (author)
Penicillin has been produced on an industrial scale for several decades. The improvements in its production process, in terms of product yields and production rates, present an unprecedented success in fermentation technology. However, the obtained product yields still remain far from their theoretical maximum. More insight in the regulation of...
doctoral thesis 2010
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Douma, R.D. (author), Batista, J.M. (author), Touw, K.M. (author), Kiel, J.A.K.W. (author), Krikken, A.M. (author), Zhao, Z. (author), Veiga, T. (author), Klaassen, P. (author), Bovenberg, R.A.L. (author), Daran, J.M. (author), Heijnen, J.J. (author), Van Gulik, W.M. (author)
Background In microbial production of non-catabolic products such as antibiotics a loss of production capacity upon long-term cultivation (for example chemostat), a phenomenon called strain degeneration, is often observed. In this study a systems biology approach, monitoring changes from gene to produced flux, was used to study degeneration of...
journal article 2011
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De Jonge, L.P. (author), Douma, R.D. (author), Heijnen, J.J. (author), Van Gulik, W.M. (author)
A sampling procedure for quantitative metabolomics in Penicillium chrysogenum based on cold aqueous methanol quenching was re-evaluated and optimized to reduce metabolite leakage during sample treatment. The optimization study included amino acids and intermediates of the glycolysis and the TCA-cycle. Metabolite leakage was found to be minimal...
journal article 2011
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Wapenaar, C.P.A. (author), Douma, H. (author)
The generalized optical theorem is an integral relation for the angle-dependent scattering amplitude of an inhomogeneous scattering object embedded in a homogeneous background. It has been derived separately for several scalar and vectorial wave phenomena. Here a unified optical theorem is derived that encompasses the separate versions for...
journal article 2012
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Douma, Y.Y. (author)
master thesis 2014
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Douma, Y.Y. (author)
report 2014
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Douma, Y.Y. (author)
master thesis 2014
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Douma, Johanna G. (author), Volkers, Karin M. (author), Vuijk, Jelle Pieter (author), Sonneveld, M.H. (author), Goossens, R.H.M. (author), Scherder, Erik J.A. (author)
Background: The number of older adults with dementia is expected to increase. Dementia is not only characterized by a decline in cognition, also other functions, for example, physical functioning change. A possible means to decrease the decline in these functions, or even improve them, could be increasing the amount of physical activity. A...
journal article 2015
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Douma, J.G. (author), Volkers, K.M. (author), Vuijk, J.P. (author), Sonneveld, M.H. (author), Goossens, R.H.M. (author), Scherder, E.J.A. (author)
Background The number of older adults with dementia is expected to increase. Dementia is not only characterized by a decline in cognition, also other functions, for example, physical functioning change. A possible means to decrease the decline in these functions, or even improve them, could be increasing the amount of physical activity. A...
journal article 2015
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Staring, M. (author), Pereira, Roberto (author), Douma, Huub (author), van der Neut, J.R. (author), Wapenaar, C.P.A. (author)
In this paper, we focus on the field data application of source-receiver Marchenko redatuming. Conventionally, a source-receiver redatumed reflection response is obtained by first applying the Marchenko method for receiver-redatuming and then performing a multi-dimensional deconvolution (MDD) for sourceredatuming (Wapenaar et al. (2014)). The...
abstract 2017
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Staring, M. (author), Pereira, R (author), Douma, H (author), van der Neut, J.R. (author), Wapenaar, C.P.A. (author)
We present an adaptive double-focusing method for applying source-receiver Marchenko redatuming to field data. Receiver redatuming is achieved by a first focusing step, where the coupled Marchenko equations are iteratively solved for the oneway Green’s functions. Next, source redatuming is typically performed by a multi-dimensional deconvolution...
conference paper 2017
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Douma, Johanna G. (author), Volkers, Karin M. (author), Engels, Gwenda (author), Sonneveld, M.H. (author), Goossens, R.H.M. (author), Scherder, Erik J.A. (author)
Background: Despite the detrimental effects of physical inactivity for older adults, especially aged residents of residential care settings may spend much time in inactive behavior. This may be partly due to their poorer physical condition; however, there may also be other, setting-related factors that influence the amount of inactivity. The...
journal article 2017
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Staring, M. (author), Pereira, Roberto (author), Douma, Huub (author), van der Neut, J.R. (author), Wapenaar, C.P.A. (author)
We have developed an adaptive double-focusing method that is specifically designed for the field-data application of source-receiver Marchenko redatuming. Typically, the single-focusing Marchenko method is combined with a multidimensional deconvolution (MDD) to achieve redatuming. Our method replaces the MDD step by a second focusing step...
journal article 2018
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